Table 5 Freeze-dried patented inventions (https://patents.google.com/)

Aripiprazole

Carboxymethyl cellulose, hydroxypropyl or ethylcellulose, polyvinylpyrrolidone

Controlled release sterile freeze-dried aripiprazole formulation and injectable formulation thereof

Otsuka Pharmaceutical Co Ltd

CA2543242C

Bioactive material comprises: cell, microbe, virus, protein, enzyme, vaccine, or a drug

cellulose acetate phthalate (CAP), carboxy-methyl-cellulose, pectin, sodium alginate, starches, and modified starches, and cyclodextrins

Dry glassy composition comprising a bioactive material

Advanced Bionutrtion Corp

US9731020B2

Sugars and hydrolysed proteins

Polysaccharide (cellulose acetate phthalate (CAP), carboxy-methyl-cellulose, pectin), disaccharides (trehalose, sucrose, lactose), and carboxylic acids

Stabilizing composition for biological materials

Intervet International BV

AU2013234931B2

Live attenuated virus

Sugar and an amino acid stabilizer

Dry formulations of vaccines that are room temperature stable

Intervet International BV

AU2014326855B2

Tetrodotoxin

Hydroxyethyl starch or hydroxypropyl cyclodextrin, sucrose, lactose, and polyglucose

Stable freeze-dried pharmaceutical formulation of tetrodotoxin

Wex Medical Ltd

CA2529598C

Docetaxel

Polyethylene glycol monomethyl ether and D, L-lactide

Freeze-dried formulation of nano polymer micelle of docetaxel and its preparation method

Simcere Pharmaceuticals Company Ltd

JP2016528187A, US9683073B2

mRNA molecule

Protamine, Trehalose

Dry powder composition comprising long-chain RNA

Curevac AG

US10729654B2

Bendamustine, Vendamustine

Mannitol

Bendamustine pharmaceutical compositions for lyophilization

Cephalon Inc

US20200237726A1, KR20170096221A

Recombinant Clostridium botulinum neurotoxin protein

Aluminum-salt adjuvant, Trehalose

Process for preparing an immunologically active adjuvant-linked dried vaccine composition

University of Colorado

US8808710B2, DK2829282T3

Anti-tissue factor

Histidine, sucrose, trehalose, mannitol, and glycine

Antibody–drug conjugate (ADC) lyophilized formulation

Genmab AS

JP2019163319A, US20200246477A1

Proteasome inhibitors

Cyclodextrin, surfactant and bulking agent

Lyophilized preparations of proteasome inhibitors

CEPHALON, INC., CEPHALON FRANCE

TWI484981B

Medicinal substances (analgesic, anti-inflammatory)

Gelatine (molecular weight of 2 × 104 g/mol)

Process to form an orally disintegrating tablet for human use

Merck Sharp and Dohme BV Intervet Inc

US9095516B2

Anoectochilus roxburghii

Xylitol, microcrystalline cellulose, polyvinylpyrrolidone, and magnesium stearate

Chewable tablet containing freeze-dried anoectochilus roxburghii powder and preparation method of chewable tablet

Minnan Normal University

CN104783180A

Metallic nanoparticles

Solvents for dispersion

Manufacturing method of coated material using freeze-drying method

OKUMURA Haruki

JPWO2014057564A1, WO2014057564A1

Virus or viral protein subunit

Non-polymeric sugar

Method of obtaining thermostable dried vaccine formulations

Merck Sharp and Dohme Corp

US9782470B2

Swine fever attenuated viruses

Mucous membrane immunologic adjuvant and immunopotentiator

Oral attenuated freeze-dried vaccine for swine fever and preparation method thereof

Zhang Zhigang

CN108969492B