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Table 3 Forced degradation results of zuclopenthixol

From: Development of stability-indicating HPLC method for quantification of pharmacopeia impurities of Zuclopenthixol and characterization of its stress degradation products by LCMS/MS

Condition

% degradation# of zuclopenthixol

% assay# of zuclopenthixol

% Mass balance$ (assay + total impurities)

Remark

Acidic

8.96

91.04

99.37

DP 1,4 and 5 were noticed

Basic

7.63

92.37

99.13

DP 2 and 6 were noticed

Peroxide

7.95

92.05

99.12

DP 3 and 6 were noticed

Thermal

2.24

97.76

99.69

No degradation was identified

UV light

2.51

97.49

99.08

No degradation was identified

  1. #average of three replicate experiments