From: Development of novel gradient RP-HPLC method for separation of dapagliflozin and its process-related impurities: insight into stability profile and degradation pathway, identification of degradants using LCMS
Sr.no
Degradation condition
DPF %
Degraded %
1
2N HCl
96.18
3.82
2
2N NaOH
96.40
3.60
3
30% H2O2
100
0
4
Heat
5
U.V