Chlorogenic acid-optimized nanophytovesicles: a novel approach for enhanced permeability and oral bioavailability

Trivedi, Hemangi R.; Puranik, Prashant K.

doi:10.1186/s43094-023-00559-0

Future Journal of Pharmaceutical Sciences

Table 1 Experimental runs and their observed responses for CGA 90H NPVs and CGA S100 NPVs using central composite design

From: Chlorogenic acid-optimized nanophytovesicles: a novel approach for enhanced permeability and oral bioavailability

Batch	X₁	X₂	X₃	CGA 90H NPVs			CGA S100 NPVs
Batch	X₁	X₂	X₃	Y₁*	Y₂*	PY*	Y₁*	Y₂*	PY*
F1	2	2	50	0.954 ± 0.04	69.02 ± 0.51	90.2 ± 0.12	0.702 ± 0.52	85.46 ± 0.63	83.78 ± 0.01
F2	3	1	40	0.778 ± 0.61	68.5 ± 0.68	82.7 ± 0.16	0.580 ± 0.15	86.69 ± 0.08	60.9 ± 0.18
F3	2	2	50	0.841 ± 0.42	75.93 ± 0.19	97.5 ± 0.43	0.710 ± 0.67	82.64 ± 0.19	81.14 ± 0.93
F4	2	3.68	50	0.798 ± 0.59	83.45 ± 0.29	98.2 ± 0.23	0.560 ± 0.23	88.0 ± 0.74	85.8 ± 0.64
F5	2	2	50	1.036 ± 0.12	81.41 ± 0.37	94.5 ± 0.21	0.734 ± 0.45	81.69 ± 0.38	86.7 ± 0.56
F6	2	2	50	0.719 ± 0.22	78.45 ± 0.91	92.0 ± 0.45	0.729 ± 0.28	83.12 ± 0.56	81.7 ± 0.38
F7	1	1	60	0.492 ± 0.53	69.69 ± 0.49	82.7 ± 0.13	0.947 ± 0.01	87.89 ± 0.68	94.6 ± 0.16
F8	2	2	66.8	0.435 ± 0.99	75.44 ± 0.04	89.8 ± 0.18	0.857 ± 0.18	85.93 ± 0.82	79.6 ± 0.18
F9	1	3	40	0.653 ± 0.58	73.72 ± 0.06	87.6 ± 0.21	0.628 ± 0.28	87.94 ± 0.73	79.6 ± 0.70
F10	0.31	2	50	0.502 ± 0.61	71.82 ± 0.33	82.9 ± 0.10	0.674 ± 0.10	87.91 ± 0.12	81.5 ± 0.22
F11	1	3	60	0.693 ± 0.01	64.6 ± 0.35	81.8 ± 0.33	0.631 ± 0.37	87.89 ± 0.34	85.2 ± 0.43
F12	2	2	50	0.687 ± 0.88	80.5 ± 0.82	94.4 ± 0.76	0.756 ± 0.43	81.14 ± 0.93	80.7 ± 0.19
F13	2	2	50	0.735 ± 0.11	77.25 ± 0.59	93.8 ± 0.50	0.731 ± 0.28	85.78 ± 0.01	78.0 ± 0.63
F14	2	0.31	50	0.922 ± 0.36	72.27 ± 0.29	92.6 ± 0.14	0.888 ± 0.45	81.45 ± 55	86.8 ± 0.55
F15	3	3	40	0.835 ± 0.72	66.13 ± 0.17	77.2 ± 0.71	0.835 ± 0.72	66.13 ± 0.17	83.7 ± 0.21
F16	3.68	2	50	0.592 ± 0.53	82.47 ± 0.18	93.3 ± 0.88	0.632 ± 0.47	85.68 ± 0.29	83.1 ± 0.12
F17	2	2	33.1	0.662 ± 0.77	74.47 ± 0.13	94.2 ± 0.81	0.832 ± 0.84	80.05 ± 0.91	82.4 ± 0.19
F18	3	3	60	0.546 ± 0.10	81.81 ± 0.37	93.3 ± 0.18	0.871 ± 0.88	82.02 ± 0.49	86.8 ± 0.46
F19	1	1	40	0.354 ± 0.45	84.01 ± 0.23	68.2 ± 0.38	0.765 ± 0.38	77.85 ± 0.16	81.3 ± 0.56
F20	3	1	60	0.977 ± 0.53	96.89 ± 1.22	97.2 ± 0.28	0.678 ± 0.22	85.43 ± 0.88	73.1 ± 0.80

Optimized batch values are highlighted
X₁: Drug: PHOSPHOLIPON® 90H/Lipoid® S100 ratio (w/w); X₂: Reaction time; X₃: Reaction temperature (°C), Y₁: Partition coefficient, Y₂: Entrapment efficiency (%), PY: Per cent yield (%)
^*Data were represented as mean ± SD (n = 3)

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