Chlorogenic acid-optimized nanophytovesicles: a novel approach for enhanced permeability and oral bioavailability

Future Journal of Pharmaceutical Sciences

Table 6 Wound contraction area and per cent wound contraction values for CGA and CGA NPVs hydrogels

Post-wounding (Days)	Blank carbopol hydrogel*	Marketed hydrogel (Silverex® heal)*	CGA hydrogel*	CGA 90H NPVs hydrogel*	CGA S100 NPVs hydrogel*
0	196.70 ± 2.3	196.70 ± 3.6	198.70 ± 3.5	201.05 ± 2.8	196.70 ± 3.7
3	132.70 ± 2.9^c (24.90%)	63.61 ± 4.1 ^a^,c (64.0%)	113.09 ± 2.8^a (36.0%)	132.7 ± 2.5 ^a^,c (34.0%)	50.26 ± 3.4 ^a^,c (71.56%)
6	95.03 ± 3.1^d (46.22%)	28.27 ± 1.6 ^b^,c (84.0%)	63.61 ± 1.9^b (64.00%)	38.48 ± 3.1 ^b^,c (80.86%)	19.63 ± 2.9 ^b,d (88.89%)
9	20.63 ± 1.9^d (87.19%)	12.56 ± 2.4 ^b^,c (92.89%)	19.43 ± 4.2^b (88.89%)	3.14 ± 2.7 ^b^,c (98.44%)	3.14 ± 3.1 ^b,d (98.62%)
12	3.14 ± 2.5^d (98.22%)	0.78 ± 0.8 ^b,d (99.56%)	0.78 ± 0.4^b (99.56%)	0.78 ± 0.23 ^b,d (99.61%)	0.78 ± 0.45 ^b,d (99.56%)
15	0.78 ± 0.5 ^d (99.56%)	∞	0.14 ± 0.02^b (99.92%)	∞	∞