Table 7 Estimated pharmacokinetic parameters after oral administration of CGA and CGA NPVs

C_max (µg/mL)

41.9 ± 1.78

47.5 ± 1.11

31.8 ± 1.56

T_max (h)

0.5

1

0.5

Elimination half-life (t_1/2) (h)

2.36

25.87

22.53

Elimination rate constant (K_el)(h⁻¹)

0.29

0.028

0.031

Area under concentration–time curve (AUC _0-t) (μg mL⁻¹ h)

110.43

327.23

183.85

Area under concentration–time curve (AUC_{0 − ∞}) (μg mL⁻¹ h)

127.32

1786.97

858.08

Mean residence time (MRT)(h)

3.51

37.75

32.64

Clearance(cl/F) [(mg)/(μg/ml⁻¹)/h⁻¹]

0.79

0.06

0.12

Volume of distribution (Vz/F) [(mg)/(μg/ml⁻¹)]

2.68

2.09

3.79