Fig. 6

In vivo targeting and delivery ability of PS nanoparticles. A A schematic diagram illustrating the experimental design. B BMD of distal tibia, and C BMD of distal femur. D BMC of distal tibia and femur. E Bone volume of distal tibia and femur. A student’s t-test was used to compare the differences between the two groups. Two-way ANOVA was performed to compare the differences among multiple groups followed by Tukey’s test. Data are shown as mean ± SD, n = 3. *P < 0.05, **P < 0.01, ***P < 0.001 vs. OVX or PS + NC. (PS + NC: SDSSD-modified PAMAM + Negative Control; PS + RNA: SDSSD-modified PAMAM + Antagomir 138-5p)