QbD-driven RP-HPLC method for novel chemo-herbal combination, in-silico, force degradation studies, and characterization of dual drug-loaded polymeric and lipidic nanocarriers

Future Journal of Pharmaceutical Sciences

Table 9 Release rate kinetics of BCA and LTB release from PLGA NPs and CBs

Models	BCA-PLGA			LTB-PLGA			BCA-CBs			LTB-CBs
Models	R²	AIC	K	R²	AIC	K	R²	AIC	K	R²	AIC	K
Zero-order	0.81	68.43	1.535	0.23	81.32	1.602	0.65	75.06	1.66	0.67	73.36	1.56
1st order	0.991	40.46	0.038	0.934	59.23	0.82	0.985	46.28	0.055	0.97	51.58	0.46
Higuchi	0.98	48.44	11.10	0.82	68.20	12.47	0.96	54.44	12.33	0.972	51.19	11.53
Hixson–Crowell	0.972	49.37	0.010	0.865	65.64	0.019	0.969	53.33	0.015	0.940	58.04	0.013
Korsmeyer–Peppas	0.986	47.10	8.89	0.87	66.67	19.61	0.966	56.08	13.44	0.973	52.9	12.36