From: Nanoemulsion drug delivery system loaded with imiquimod: a QbD-based strategy for augmenting anti-cancer effects
Independent variable
Levels used
− 1
0
+ 1
X1: % Oil concentration
15
18
21
X2: % Smix concentration
47
54
61
Response: dependent variable
 Y1 Globule size in nm
Minimum
 Y2 Zeta potential in mV
Maximum