Table 10 Stability results of Olanzapine in plasma of rabbit under different storage conditions
Stability | Storage condition | Conc. level | Measured conc (ng/ml) (Mean ± SD, n = 6) | % RSD | % Recovery |
|---|---|---|---|---|---|
Bench top stability | 18 h at room temperature | 10 | 10.215 ± 1.2 | 0.96 | 99.64 |
20 | 20.324 ± 0.8 | 0.84 | 99.59 | ||
30 | 29.042 ± 2.3 | 0.75 | 99.84 | ||
Autosampler stability | 24 h in autosampler at room temperature | 10 | 10.174 ± 0.7 | 1.92 | 99.47 |
20 | 20.236 ± 2.4 | 0.53 | 99.53 | ||
30 | 30.524 ± 0.6 | 1.14 | 99.54 | ||
Long-term stability | 28 days at (− 20 ± 3)°C | 10 | 9.231 ± 1.3 | 2.54 | 86.46 |
20 | 20.529 ± 2.2 | 0.53 | 87.42 | ||
30 | 30.112 ± 3.1 | 0.49 | 86.86 | ||
Freeze thaw stability | 24 h at (− 28 ± 5)°C then exposed to three freeze and thawed cycles | 10 | 10.432 ± 1.5 | 1.54 | 99.02 |
20 | 19.362 ± 0.47 | 1.10 | 98.37 | ||
30 | 30.047 ± 1.11 | 0.76 | 98.45 | ||
Wet extract stability | 18 h at 2–8 °C | 10 | 10.321 ± 0.6 | 1.55 | 98.48 |
20 | 19.865 ± 2.3 | 0.43 | 99.24 | ||
30 | 29.745 ± 1.7 | 0.28 | 98.61 | ||
Dry extract stability | 18 h at (− 20 ± 3)°C | 10 | 10.341 ± 3.5 | 0.95 | 98.85 |
20 | 20.552 ± 0.7 | 1.43 | 98.74 | ||
30 | 30.639 ± 4.1 | 0.52 | 99.53 | ||
Short-term stability | 7 days at (5 ± 3)°C | 10 | 10.063 ± 1.9 | 0.89 | 93.57 |
20 | 20.597 ± 3.2 | 0.33 | 94.54 | ||
30 | 30.552 ± 4.6 | 0.71 | 94.96 |