Antioxidant and acetylcholinesterase inhibitory activities, in silico analyses, and anti-Alzheimer’s disease potential of leaf extracts of three Nigerian endemic medicinal plants (Spondias mombin, Carica papaya and Kalanchoe crenata)

Future Journal of Pharmaceutical Sciences

Table 5 Correlation coefficients of the total flavonoids, total phenolics, total tannins and acetylcholinesterase inhibitory activity with antioxidant activities of Spondias mombin, Carica papaya and Kalanchoe crenata

Antioxidant test	R²
Antioxidant test	AChE	Total flavonoid	Total phenolic	Total tannin
DPPH^· scavenging activity	0.8295	0.6457	0.6177	0.6316
Superoxide radical scavenging activity	0.5485	0.3684	0.9046	0.8654
Nitric oxide radical scavenging activity	0.7337	0.5463	0.8705	0.9074
Hydroxyl radical scavenging activity	0.6595	0.4387	0.9489	0.9074
ABTS^·+ scavenging activity	0.6214	0.1754	0.4855	0.4.715
Iron chelating	0.5876	0.7011	0.9580	0.9699
CUPRAC	0.6295	0.3880	0.9580	0.9294
Lipid peroxidation inhibitory activity	0.7214	0.0529	0.0689	0.06281
Acetylcholinesterase inhibitory activity	–	0.8306	0.6699	0.7012

Correlation is significant at the 0.05 level (one-tailed)
DPPH 1,1-diphenyl-2-picrylhydrazyl, ABTS 2,2′-Azinobis-(3-ethylbenzthiazoline-6-sulphonate), CUPRAC Cupric ion reducing antioxidant capacity. R² coefficient of determination