Table 1 Different techniques for formulating nanocrystals, including both top-down and bottom-up approaches, as well as combinational technologies [19,20,21,22]
From: Nanocrystals: an emerging paradigm for cancer therapeutics
Formulation methodology | Formulation techniques | Mechanism of size reduction |
|---|---|---|
Top-down approach technologies | Media milling | Impact and attrition |
High-pressure homogenization | High shear and high pressure | |
Bottom-up approach technologies | Precipitation or crystallization | Precipitation or controlled crystallization processes |
Combinational technologies | Hybrid approaches | High energy driven |
Supercritical fluid technology | Uses super critical fluids |