Table 14 Optimized formulation of conventional and pH-sensitive formulation
From: Preparation and in vitro evaluation of BBG-250 loaded liposomal formulation for anticancer potential
Formulation code | Lipid ratio | Drug (mg) | Sonication time | Particle size (nm) | PDI | Entrapment efficiency | Zeta potential |
|---|---|---|---|---|---|---|---|
P1 | 3:2:3:0.3 | 4 | 4 min | 325 ± 1.6 | 0.230 | 49% |  − 53 |
P2 | 3:3:3:0.3 | 4 | 4 min | 370 ± 0.2 | 0.165 | 52% |  − 55 |
P3 | 3:4:3:0.3 | 4 | 4 min | 390 ± 1.3 | 0.599 | 75% |  − 37 |
P4 | 4:2:3:0.3 | 4 | 4 min | 156 ± 1.4 | 0.230 | 72% |  − 20 |
P5 | 4:3:3:0.3 | 4 | 4 min | 118 ± 1.2 | 0.165 | 78% |  − 25 |
P6 | 4:4:3:0.3 | 4 | 4 min | 290 ± 0.8 | 0.599 | 65% |  − 47 |
P7 | 5:2:3:0.3 | 4 | 4 min | 328 ± 0.6 | 0.230 | 69% |  − 30 |
P8 | 5:3:3:0.3 | 4 | 4 min | 425 ± 1.2 | 0.165 | 70% |  − 22 |
P9 | 5:4:3:0.3 | 4 | 4 min | 609 ± 0.6 | 0.599 | 45% |  − 41 |
P10 | 8:2:0.3 | 4 | 4 min | 425 ± 0.6 | 0.215 | 35 |  − 59 |
P11 | 7:3:0.3 | 4 | 4 min | 125 ± 0.3 | 0.316 | 64 |  − 28 |
P12 | 6:4:0.3 | 4 | 4 min | 356 ± 0.9 | 0.366 | 52 |  − 38 |