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Table 1 Assay parameters and results of determination of pure samples of CAR and IVA by the proposed methods

From: A unique revolutionary eco-friendly spectrophotometric technique for solving the spectral overlap in the determination of carvedilol and ivabradine in their binary combination: stability study

 

CAR

IVA

RD

FDW-SS

CC-SS

ITAD-RS

RD

FDW-SS

CC-SS

ITAD-RS

Linearity (µg/ml)

3.0–30.0

3.0–30.0

Slope

0.6057

0.0408

0.43

0.0379

Intercept

0.0044

0.0017

0.025

0.0173

Correlation coefficient (r)

0.9998

0.9998

0.9999

0.9999

Accuracy(Mean ± SD)

99.38 ± 0.92

98.45 ± 0.851

99.47 ± 1.41

99.15 ± 0.874

*RSD%a

0.791

1.244

0.823

1.202

**RSD%b

0.839

1.357

1.229

1.323

LOD

0.258

0.290

0.272

0.204

LOQ

0.783

0.878

0.823

0.618

  1. *RSD%a, **RSD%b: the intra-day AND inter-day, respectively, (n = 3) relative standard deviation of concentrations (6.0, 20.0, 25.0 µg/ml for CAR and 6.0, 18.0, 25.0 µg/ml for IVA)