Table 3 Advantages of NLCs compared to SLNs limitations regarding ocular drug delivery
Advantages of NLCs | Disadvantages of SLNs |
|---|---|
Superior encapsulation efficiency Excellent ocular permeability Proper pharmacokinetic characteristics Extended and controlled drug release Maintaining adequate drugs’ concentrations within the aqueous humor, vitreous humor, and retina -Increasing pre-corneal drug retention Increasing drugs’ corneal permeation Increasing ocular bioavailability and distribution Positively-charged NLCs have shown to promote a prolonged ocular residence time, circumventing ocular toxicity owing to their close contact with negatively charged mucus membrane Superior biocompatibility and stability | Initial burst release of SLNs Low drug loading efficiency SLNs for ocular drug delivery have not recently assessed through extensive clinical trials, and most investigations have only undergone in-vitro evaluations Retinal cell toxicity of SLNs has not been thoroughly studied till current date |