Antidiarrhoeal screening of Himalayan edible plant Begonia rubrovenia and its marker followed by its validation using computational analysis

Future Journal of Pharmaceutical Sciences

Table 2 Effect of B. rubrovenia extract on castor oil induced diarrhoea model

Groups	Onset time (min)	Total no of faeces	Total no of wet faeces	Loss in body weight	Total wt of faeces	Mean defecation in 4 h	Diarrhoea score	% Protection
Normal		4.50 ± 0.22		0.16 ± 0.005	0.27 ± 0.01	1.12 ± 0.05	–	100
Castor oil	52.33 ± 2.29	15.33 ± 0.76^a	10.83 ± 0.74	1.03 ± 0.05^a	2.07 ± 0.05^a	3.83 ± 0.19^a	28.33 ± 2.04	–
EBV 100	68.83 ± 3.04	11.33 ± 0.49^ab	7.83 ± 0.30^b	0.90 ± 0.04^a	1.82 ± 0.08^ab	2.83 ± 0.12^ab	15.83 ± 0.79^b	44.11
EBV 200	119.83 ± 5.54^b	5.66 ± 0.33^b	3.50 ± 0.22^b	0.64 ± 0.03^ab	0.93 ± 0.04^ab	1.41 ± 0.08^b	10.50 ± 0.61^b	62.93
EBV 300	120.83 ± 6.20^b	6.50 ± 0.42^b	3.33 ± 0.21^b	0.63 ± 0.03^ab	0.94 ± 0.03^ab	1.62 ± 0.10^b	9.83 ± 0.47^b	65.29
Quercetin	109.50 ± 5.85^b	7.66 ± 0.33^ab	3.33 ± 0.21^b	0.72 ± 0.03^ab	1.10 ± 0.06^ab	1.91 ± 0.08^ab	11.00 ± 0.44^b	61.17
Loperamide	126.66 ± 6.95^b	5.83 ± 0.40^b	2.16 ± 0.47^b	0.56 ± 0.02^ab	0.66 ± 0.03^ab	1.45 ± 0.10^b	8.00 ± 0.73^b	71.76

Values are mean ± S.E.M. (n = 6)
In table EBV Ethanolic extract of Begonia rubrovenia at dose level of 100, 200 and 300 mg/kg, p.o.
^apP < 0.05 vs. Normal