Table 1 Summary of the composition of the drug free (blank) ocular inserts formulations
Formula | Polymer | Polymer concentration %w/v | Plasticiser (glycerine) (%v/v) | Solvent volume (mL) |
|---|---|---|---|---|
F1 | HPMC | 0.5 | 0.25 | 50 |
F2 | 30 | |||
F3 | 20 | |||
F4 | HPMC | 1.0 | 0.25 | 50 |
F5 | 30 | |||
F6 | 20 | |||
F7 | HPMC | 1.5 | 0.25 | 50 |
F8 | 30 | |||
F9 | 20 | |||
F10 | HPMC | 2.0 | 0.25 | 50 |
F11 | 30 | |||
F12 | 20 | |||
F13 | PVA | 0.5 | 1.0 | 50 |
F14 | 30 | |||
F15 | 20 | |||
F16 | PVA | 1.0 | 1.0 | 50 |
F17 | 30 | |||
F18 | 20 | |||
F19 | PVA | 1.5 | 1.0 | 50 |
F20 | 30 | |||
F21 | 20 | |||
F22 | PVA | 2.0 | 1.0 | 50 |
F23 | 30 | |||
F24 | 20 | |||
F25 | PVA | 3.0 | 1.0 | 50 |
F26 | 30 | |||
F27 | 20 | |||
F28 | HPMC + PVA | 1.5 + 2.0 | 1.0 | 50 |
F29 | 30 | |||
F30 | HPMC + PVA | 1.0 + 1.5 | 1.0 | 50 |
F31 | 30 | |||
F32 | 20 | |||
F33 | HPMC + PVA | 1.0 + 1.0 | 1.0 | 50 |
F34 | 30 | |||
F35 | 20 |