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Future Journal of Pharmaceutical Sciences
Fig. 9 | Future Journal of Pharmaceutical Sciences

Fig. 9

From: Ethnozoological importance of Eisenia fetida and experimental validation of its anticancer activity in ascites Dalton’s lymphoma (DL) bearing mice

Fig. 9

Ultrastructural features of DL cells. The blue arrow in the control shows DL cells a with distinct mitochondria cristae, The blue arrow showing mitochondrial damage and nuclear fragmentation after CDDP treatment from 96 h b, c and d, EFP treatment for 24-96 h e–l showed pronounced vacuoles and mitochondrial EFP-treated tumour-bearing mice also developed similar structural features in DL cells as observed for CDDP treatment as indicated by the blue arrows. The mitochondria showed rounded deformed cristae and a few vacuoles at 24 h of treatment (Fig. 9e–f). At 48 h to 96 h of EFP treatment, the DL cells showed fragmented nuclei, prominent vacuoles, membrane disorganisation, and disordered organisation of mitochondrial cristae with severe damage observed as indicated by the blue arrows (Fig. 9 g–l)

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