Efficacy evaluation of Berberis aristata and Silybum marianum fixed dose combination on glycaemic and insulin resistance parameters in adult population: a systematic review and meta-analysis of randomized controlled trials

Future Journal of Pharmaceutical Sciences

Table 4 Result of sensitivity analysis using leave-one-study-out method

Studies (removed from analysis)	I² value (%)	Estimate	95% CI	p-value
Glucose level
Overall	90	− 5.302	− 9.905 to − 0.698	0.024
Derosa [36]	91	− 6.433	− 12.799 to − 0.067	0.048
Derosa [37]	85	− 6.980	− 12.078 to − 1.882	0.007
Pierro [38]	92	− 5.969	− 10.836 to − 1.102	0.016
Derosa [39]	83	− 4.498	− 9.906 to 0.909	0.103
Derosa [41]	89	− 3.158	− 7.518 to 1.203	0.156
HbA1c level
Overall	90	− 0.693	− 1.017 to − 0.370	< 0.001
Pierro [38]	91	− 0.776	− 1.133 to − 0.420	< 0.001
Guarino [40]	93	− 0.686	− 1.156 to − 0.215	0.004
Derosa [41]	92	− 0.754	− 1.136 to − 0.372	< 0.001
Guarino [42]	39	− 0.563	− 0.732 to − 0.394	< 0.001
HOMA-IR score
Overall	99	− 0.644	− 1.358 to 0.07	0.077
Derosa [37]	99	− 0.765	− 1.693 to 0.163	0.106
Derosa [39]	99	− 0.763	− 1.701 to 0.175	0.111
Guarino [40]	99	− 0.724	− 1.614 to 0.166	0.111
Guarino [42]	0	− 0.303	− 0.394 to − 0.211	< 0.001