Table 10 Different parameters of simvastatin transdermal patch
From: Optimization of simvastatin transdermal patch for hyperlipidemia treatment in rat model
Formulation | Thickness (mm) | Swelling Index (%) | Moisture content (%) | Moisture Uptake (%) | Drug content (%) |
|---|---|---|---|---|---|
SIM-TP1 | 0.55 ± 0.01 | 45.02 ± 0.79 | 6.21 ± 0.11 | 7.21 ± 0.21 | 94.52 ± 0.75 |
SIM-TP2 | 0.54 ± 0.02 | 43.45 ± 0.86 | 5.52 ± 0.09 | 6.25 ± 0.18 | 92.73 ± 0.68 |
SIM-TP3 | 0.52 ± 0.08 | 50.61 ± 0.67 | 8.31 ± 0.13 | 10.53 ± 0.12 | 94.42 ± 0.67 |
SIM-TP4 | 0.56 ± 0.07 | 57.43 ± 0.44 | 5.15 ± 0.08 | 7.69 ± 0.14 | 89.81 ± 0.60 |
SIM-TP5 | 0.56 ± 0.05 | 53.72 ± 0.65 | 8.50 ± 0.14 | 11.42 ± 0.17 | 95.21 ± 0.58 |
SIM-TP6 | 0.57 ± 0.03 | 45.43 ± 0.78 | 5.83 ± 0.12 | 6.22 ± 0.14 | 95.43 ± 0.56 |
SIM-TP7 | 0.58 ± 0.08 | 55.21 ± 068 | 6.31 ± 0.11 | 7.32 ± 0.11 | 95.7 ± 0.57 |
SIM-TP8 | 0.60 ± 0.05 | 45.18 ± 0.75 | 6.42 ± 0.11 | 8.74 ± 0.10 | 94.63 ± 0.62 |
SIM-TP9 | 0.58 ± 0.04 | 55.73 ± 0.85 | 6.23 ± 0.10 | 8.82 ± 0.12 | 95.15 ± 0.68 |
SIM-TP10 | 0.59 ± 0.02 | 54.34 ± 0.68 | 7.32 ± 0.13 | 8.41 ± 0.11 | 95.56 ± 0.66 |
SIM-TP11 | 0.60 ± 0.05 | 59.77 ± 0.57 | 8.71 ± 0.12 | 11.62 ± 0.21 | 98.75 ± 0.78 |
SIM-TP12 | 0.62 ± 0.08 | 62.38 ± 0.69 | 5.24 ± 0.11 | 9.51 ± 0.10 | 98.35 ± 0.77 |
SIM-TP13 | 0.60 ± 0.05 | 56.23 ± 0.57 | 8.95 ± 0.12 | 10.44 ± 0.12 | 93.13 ± 0.78 |
SIM-TP14 | 0.59 ± 0.02 | 53.17 ± 0.68 | 5.18 ± 0.10 | 6.92 ± 0.14 | 90.76 ± 0.65 |
SIM-TP15 | 0.62 ± 0.06 | 57.24 ± 0.88 | 6.66 ± 0.09 | 7.51 ± 0.11 | 96.64 ± 0.85 |