Table 5 Design of experiment and the responses
From: Optimization of simvastatin transdermal patch for hyperlipidemia treatment in rat model
Run | Factor A | Factor B | Factor C | Response 1 | Response 2 |
|---|---|---|---|---|---|
HPMC K100 (%) | ERL 100 (%) | PEG (%) | Folding Endurance | In-vitro release (%) | |
1 | 1 | 0.1 | 50 | 287 ± 4 | 53.58 ± 0.05 |
2 | 0.2 | 1 | 30 | 40 ± 6 | 53.88 ± 0.03 |
3 | 1.8 | 1 | 30 | 250 ± 4 | 52.69 ± 0.04 |
4 | 0.2 | 0.55 | 10 | 60 ± 5 | 43.91 ± 0.05 |
5 | 1.8 | 0.1 | 30 | 275 ± 8 | 48.79 ± 0.01 |
6 | 1 | 0.55 | 30 | 43 ± 2 | 49.92 ± 0.05 |
7 | 1 | 0.55 | 30 | 244 ± 7 | 42.12 ± 0.04 |
8 | 1 | 1 | 50 | 280 ± 5 | 51.04 ± 0.02 |
9 | 1 | 0.55 | 30 | 125 ± 8 | 47.51 ± 0.03 |
10 | 1 | 1 | 10 | 187 ± 9 | 40.56 ± 0.02 |
11 | 1.8 | 0.55 | 10 | 143 ± 7 | 38.51 ± 0.01 |
12 | 0.2 | 0.55 | 50 | 50 ± 3 | 55.52 ± 0.03 |
13 | 1.8 | 0.55 | 50 | 166 ± 6 | 52.53 ± 0.05 |
14 | 0.2 | 0.1 | 30 | 60 ± 4 | 54.18 ± 0.02 |
15 | 1 | 0.1 | 10 | 132 ± 5 | 50.66 ± 0.01 |