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Future Journal of Pharmaceutical Sciences

Table 1 Coded values of 32 full factorial design for formulation of cubosomes

From: Dual drug-loaded cubosome nanoparticles for hepatocellular carcinoma: a design of experiment approach for optimization and in vitro evaluation

Independent variables

Levels

Low (− 1)

Medium (0)

High (+1)

X1 = GMO

2.5

3.75

5

X2 = Poloxamer 407

0.5

1.25

2

Independent variables

Constraints

Importance

X1 = GMO

In range

+++

X2 = Poloxamer 407

In range

+++

Dependent variables

Y1 = Particle size

Minimum

+++

Y2 = % EE

Maximum

+++

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