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Future Journal of Pharmaceutical Sciences

Table 2 CCD experimental runs with obtained response

From: Dual drug-loaded cubosome nanoparticles for hepatocellular carcinoma: a design of experiment approach for optimization and in vitro evaluation

Formulation code

X1 (%)

X2 (%)

Y1

Y2

C1

2.5

0.5

102.36

76.43

C2

2.5

1.25

109.75

59.54

C3

2.5

2

118.24

53.28

C4

3.75

0.5

124.44

79.83

C5

3.75

1.25

149.36

61.2

C6

3.75

1.25

151.27

62.3

C7

3.75

1.25

154.2

64.83

C8

3.75

1.25

172.7

65.9

C9

5

0.5

179.6

81.23

C10

5

1.25

216

67.28

C11

5

2

222.4

54.01

  1. X1 = amount of GMO, X2 = amount of Poloxamer 407, Y1 = Particle size, Y2 = Entrapment efficiency
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