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Table 4 The generated model analysis results

From: Evaluating the prediction power and accuracy of two smart response surface experimental designs after revisiting repaglinide floating tablets

Design type

Central composite

D-optimal

Significance

Significant

Significant

 

P < 0.0001

P < 0.0001

Model type

Quadratic

Quadratic

R-squared

0.9991

0.9210

Adjusted R-squared

0.9984

0.8736

Predicted R-squared

0.9935

0.7921

Adequate precision

122.830

14.161

Generated equation

\(\begin{aligned} & {\text{Floating Lag Time}} = - {7828}{\text{.09234}} \\ & \quad + {1007}{\text{.19857 * OG}}\;{\text{concentration}} \\ & \quad + {880}{\text{.39460 * HPMC K15M}} \\ & \quad + {1364}{\text{.29190 * Xanthan}}\;{\text{Gum}} \\ & \quad - {15}{\text{.58000 * OG}}\;{\text{concentration * HPMC K15M}} \\ & \quad - {11}{\text{.00000 * OG}}\;{\text{concentration * Xanthan}}\;{\text{Gum}} \\ & \quad - {2}{\text{.75000 * HPMC K15M * Xanthan}}\;{\text{Gum}} \\ & \quad + {4}{\text{.43181 * OG}}\;{\text{concentration}}^{{2}} \\ & \quad - {43}{\text{.99831 * HPMC K15M}}^{{2}} \\ & \quad - {125}{\text{.72119 * Xanthan}}\;{\text{Gum}}^{{2}} \\ \end{aligned}\)

\(\begin{aligned} & {\text{Floating Lag Time}} = + {76}{\text{.99172}} \\ & \quad + {26}{\text{.21690 * OG}}\;{\text{concentration}} \\ & \quad - {27}{\text{.47543 * HPMCK15M}} \\ & \quad + {1}{\text{.21784 * Xanthan}}\;{\text{Gum}} \\ & \quad - {16}{\text{.51078 * OG}}\;{\text{concentration * HPMCK15M}} \\ & \quad - {10}{\text{.24740 * OG}}\;{\text{concentration * Xanthan}}\;{\text{Gum}} \\ & \quad - {2}{\text{.74859 * HPMCK15M * Xanthan}}\;{\text{Gum}} \\ & \quad + {17}{\text{.47349 * OG}}\;{\text{concentration}}^{{2}} \\ & \quad + {4}{\text{.43398 * HPMCK15M}}^{{2}} \\ & \quad - {1}{\text{.65511 * Xanthan}}\;{\text{Gum}}^{{2}} \\ \end{aligned}\)