Table 6 Constrains for optimization of nanosuspension
Name | Goal | Lower limit | Upper limit | Lower weight | Upper weight | Importance |
|---|---|---|---|---|---|---|
A:Polymer concentration | Is in range | 1 | 2 | 1 | 1 | 3 |
B:Speed of rotation | Is in range | 1000 | 2000 | 1 | 1 | 3 |
Particle size | Minimize | 304.4 | 544.1 | 1 | 1 | 4 |
PI | Is in range | 0.37 | 0.42 | 1 | 1 | 3 |
Zeta potential | Is in range | -45.6 | -25.6 | 1 | 1 | 3 |
%Drug content | Maximize | 96.2 | 99.75 | 1 | 1 | 4 |
% Drug entrapment efficiency | Maximize | 94.68 | 98.92 | 1 | 1 | 4 |