Solvent fractions of Vitellaria paradoxa root extract suppress phenylhydrazine-mediated jaundice in Wistar rats

Future Journal of Pharmaceutical Sciences

Table 3 Body weight changes in phenylhydrazine-induced hyperbilirubinemic Wistar rats treated with solvent fraction of Vitellaria paradoxa root extracts

GROUP	DAY 1 (g)	DAY 28 (g)	BWC (g)
Control	81.77 ± 16.91	123.39 ± 17.21	+ 41.62 ± 0.30^bc
PHZ only	84.35 ± 18.16	53.17 ± 17.31	− 31.18 ± 0.85*
PHZ + n-hexane	85.21 ± 16.21	126.57 ± 17.02	+ 41.36 ± 0.81^bc
PHZ + n-butanol	86.50 ± 11.08	73.67 ± 13.3	+ 32.17 ± 2.22 *^c
PHZ + ethylacetate	73.29 ± 19.13	63.27 ± 20.21	− 10.02 ± 1.08*^c
PHZ + aqueous	83.86 ± 11.89	54.34 ± 13.54	− 29.52 ± 1.65*

50 mg/kg of phenylhydrazine intraperitoneal (PHZ): n-hexane, n-butanol, ethylacetate and aqueous represents the different fractions of the extracts: BWC: body weight change: values are presented as mean ± SD (n = 7):*values differ significantly from control (p < 0.05): ^bvalues are not significantly different from each other (p < 0.05): ^cvalues differ significantly as compared with PHZ only (p < 0.05)