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Future Journal of Pharmaceutical Sciences

Table 4 Superoxide dismutase activity (SOD) and malondialdehyde (MDA) levels changes in phenylhydrazine-induced hyperbilirubinemic Wistar rats treated with solvent fraction of Vitellaria paradoxa root extracts

From: Solvent fractions of Vitellaria paradoxa root extract suppress phenylhydrazine-mediated jaundice in Wistar rats

Group

SOD (units/mg)

MDA (nmol/l)

Control

2.64 ± 0.35bc

24.35 ± 0.36bc

PHZ only

1.22 ± 0.13*

44.08 ± 0.23*

PHZ + n-hexane

2.30 ± 0.35bc

22.39 ± 0.81bc

PHZ + n-butanol

1.29 ± 0.63*c

39.92 ± 0.68*c

PHZ + ethylacetate

1.38 ± 0.23*c

38.74 ± 0.41*c

PHZ + aqueous

1.43 ± 0.16*

38.04 ± 0.41*

  1. 50 mg/kg of phenylhydrazine intraperitoneal (PHZ): n-hexane, n-butanol, ethylacetate and aqueous represents the different fractions of the extracts: SOD: superoxide dismutase: MDA: malondialdehyde: values are presented as mean ± SD (n = 7):*values differ significantly from control (p < 0.05): bvalues are not significantly different from each other (p < 0.05): cvalues differ significantly as compared with PHZ only (p < 0.05)
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