Table 1 Independent factors with their levels and dependent factors with their constraints in Box–Behnken design for the development of NDFX-loaded transethosomes
Factors | Levels | ||
|---|---|---|---|
Low | Medium | High | |
Independent factors | |||
A. PC90 (%) | 2 | 3 | 4 |
B. Tween 80 (%) | 0.2 | 0.3 | 0.4 |
C. Ethanol (%) | 20 | 25 | 30 |
Dependent factors | |||
Entrapment E. (%) | Maximize | ||
Vesicle size (nm) | Minimize | ||
Zeta potential (mV) | Maximize | ||