Table 5 Results of the response of experimental Box–Behnken design for optimization of NDFX-loaded transethosomes
Formulation code | PC 90 (%) | Tween 80 (%) | Ethanol (%) | Entrapment (%) | Vesicle size (nm) | Zeta potential (mV) |
|---|---|---|---|---|---|---|
1 | 2 | 0.3 | 30 | 54.71 | 100.65 | − 32.25 |
2 | 3 | 0.3 | 25 | 73.89 | 128.2 | − 27.88 |
3 | 3 | 0.2 | 20 | 80.76 | 173.01 | − 33.72 |
4 | 2 | 0.4 | 25 | 57.7 | 97.12 | − 34.34 |
5 | 3 | 0.3 | 25 | 74.01 | 128.9 | − 29.98 |
6 | 3 | 0.4 | 20 | 72.73 | 142.25 | − 29.99 |
7 | 3 | 0.3 | 25 | 74.48 | 128.6 | − 30.25 |
8 | 3 | 0.3 | 25 | 73.61 | 126.9 | − 29.77 |
9 | 3 | 0.2 | 30 | 71.61 | 134.9 | − 27.74 |
10 | 4 | 0.3 | 30 | 67.48 | 142.21 | − 22.43 |
11 | 3 | 0.4 | 30 | 43.64 | 96.74 | − 24.72 |
12 | 4 | 0.3 | 20 | 79.6 | 188.51 | − 19.95 |
13 | 2 | 0.2 | 25 | 72.82 | 151.18 | − 29.2 |
14 | 3 | 0.3 | 25 | 73.73 | 138.3 | − 28.35 |
15 | 2 | 0.3 | 20 | 79.95 | 156.96 | − 34.18 |
16 | 4 | 0.2 | 25 | 81.05 | 187.34 | − 21.51 |
17 | 4 | 0.4 | 25 | 63.72 | 160.17 | − 17.12 |