Development of docetaxel-loaded (Soluplus®–PF108) mixed micelles vacuum foam-dried product for improved stability and melanoma treatment by QbD approach

Future Journal of Pharmaceutical Sciences

Table 1 Formulation compositions using 3² full factorial design and results of their characterization

Batch code	Drug (mg)	Soluplus® (mg)	PF108 (mg)	% EE (%)	MPS (nm)	DLC (%)
R1	2.5	182	22	60.79 ± 2.23	80.5 ± 1.40	20.43 ± 0.75
R2	2.5	182	45	64.51 ± 1.22	74.8 ± 2.89	23.75 ± 0.91
R3	2.5	182	67	65.73 ± 3.56	74.7 ± 4.59	26.14 ± 1.27
R4	2.5	365	22	72.06 ± 2.27	72.8 ± 03.27	28.02 ± 1.41
R5	2.5	365	45	74.81 ± 4.27	71.4 ± 1.24	29.27 ± 0.70
R6	2.5	365	67	74.64 ± 1.82	72.3 ± 3.81	25.11 ± 0.69
R7	2.5	547	22	73.04 ± 2.43	72.4 ± 4.78	21.23 ± 0.34
R8	2.5	547	45	72.54 ± 4.65	72.7 ± 3.25	19.46 ± 1.25
R9	2.5	547	67	70.70 ± 1.28	77.8 ± 4.7	18.12 ± 0.89