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Table 3 Stability study of DSP-MMs

From: Development of docetaxel-loaded (Soluplus®–PF108) mixed micelles vacuum foam-dried product for improved stability and melanoma treatment by QbD approach

Sampling time

DSP MMs

DSP MMs VFD product

%EE (%)

MPS (nm)

%DLC (%)

%EE (%)

MPS (nm)

Moisture content (%)

Reconstitution time (sec)

%DLC (%)

0 Day

74.81 ± 0.27

71.4 ± 0.52

29.27 ± 0.70

79.98 ± 0.97

82.70 ± 0.98

2.25 ± 0.36

46 ± 5

98.2 ± 1.3

1 Month

72.5 ± 0.16

75.8 ± 1.12

29.07 ± 1.80

79.51 ± 1.12

82.84 ± 0.75

2.40 ± 0.51

49 ± 4

98.1 ± 0.9

2 Months

70.19 ± 0.32

79.2 ± 2.26

28.87 ± 0.90

78.87 ± 0.58

82.84 ± 0.75

2.80 ± 0.76

52 ± 3

97.4 ± 1.1

3 Months

66.28 ± 0.57

89.1 ± 1.48

28.77 ± 0.80

78.24 ± 0.72

84.79 ± 0.87

2.96 ± 0.84

55 ± 4

96.7 ± 0.7