Fig. 3

Representative histological photomicrographs of H&E-stained rat pancreatic Sects. (400x). A The control group shows a pale-stained islet of Langerhans surrounded by a darkly stained closely packed pancreatic acini. The acini are formed of pyramidal cells displaying apical acidophilia and basal basophilia with vesicular nuclei and prominent nucleoli. B & C Groups STZ-30 and STZ-30-Cap illustrate degenerated islets of Langerhans with vacuolations (arrows) and a few depleted β-cells that display darkly stained nuclei (arrow heads). D & E Group STZ-40 illustrates a degenerated islet of Langerhans with few vacuolations (arrows) and few depleted β-cells that display darkly stained nuclei (arrow heads). Group STZ-40-Cap exhibits more vacuolations (arrows) in islets of Langerhans and more depleted B-cells with darkly stained nuclei (arrow heads). F & G. Group STZ-50 displays marked degeneration of islets of Langerhans with vacuolations (arrows) and many depleted β-cells. Group STZ-50-Cap shows massive degeneration with vacuolations (arrows) and most of the cells are depleted (arrow heads). H. Histogram representing mean area % Islet of Langerhans size; *denotes significant difference compared to control, # denotes significant difference compared to STZ-30, $ denotes significant difference compared to STZ-30-Cap, € denotes significant difference compared to STZ-40, ¥ denotes significant difference compared to STZ-40-Cap, and @ denotes significant difference compared to STZ-50. STZ Streptozotocin, Cap Captopril