Fig. 4
From: Size-dependent effects of niosomes on the penetration of methotrexate in skin layers
A Graphical representation of formulation optimization with ratio 6:2:2 (Span 60:CH:SPC); a vesicle size (nm); b PDI; c Zeta Potential (mV); d entrapment efficiency (%). B Images showing the particle-size distribution of the optimized formulations (NIO 13, 14, 17, and 18) prepared using a ratio of Span 60:CH:SPC (6:2:2). C Images showing the zeta potential of the optimized formulations (NIO 16 and 17) prepared using a ratio of Span 60:CH:SPC (6:2:2)