Table 1 The formulations of niosomes with different ratios of ingredients and sonication time, along with the results of particle sizes, zeta potential, PDI, and entrapment efficiency
From: Size-dependent effects of niosomes on the penetration of methotrexate in skin layers
Formulation code | Span60:CH:SPC | Sonication time (min) | Vesicle size (nm) | PDI | Zeta potential (mV) | Entrapment efficiency (%) |
|---|---|---|---|---|---|---|
Nio1 | 4:2:2 | 0 | 1160.3 | 0.11 | − 48.8 | 68.13 |
Nio2 | 4:2:2 | 2 | 976.9 | 0.36 | − 45.7 | 67.43 |
Nio3 | 4:2:2 | 4 | 843.7 | 0.44 | − 40.3 | 64.36 |
Nio4 | 4:2:2 | 6 | 777.5 | 0.31 | − 32.2 | 58.97 |
Nio5 | 4:2:2 | 8 | 575.2 | 0.35 | − 38.5 | 58.04 |
Nio6 | 4:2:2 | 10 | 289.5 | 0.43 | − 31.2 | 35.02 |
Nio7 | 5:2:2 | 0 | 1406.3 | 0.40 | − 54.8 | 56.23 |
Nio8 | 5:2:2 | 2 | 965.9 | 0.23 | − 45.7 | 53.43 |
Nio9 | 5:2:2 | 4 | 765.7 | 0.35 | − 44.3 | 48.36 |
Nio10 | 5:2:2 | 6 | 613.5 | 0.25 | − 40.2 | 50.97 |
Nio11 | 5:2:2 | 8 | 535.2 | 0.33 | − 35.5 | 44.03 |
Nio12 | 5:2:2 | 10 | 425.5 | 0.13 | − 28.2 | 30.07 |
Nio13 | 6:2:2 | 0 | 982.3 | 0.22 | − 38.8 | 76.23 |
Nio14 | 6:2:2 | 2 | 783.9 | 0.30 | − 41.7 | 73.43 |
Nio15 | 6:2:2 | 4 | 707.7 | 0.23 | − 32.3 | 56.36 |
Nio16 | 6:2:2 | 6 | 671.5 | 0.39 | − 27.8 | 62.97 |
Nio17 | 6:2:2 | 8 | 597.2 | 0.49 | − 23.3 | 55.05 |
Nio18 | 6:2:2 | 10 | 205.2 | 0.42 | − 29.2 | 50.02 |