Fig. 8
From: Natural product-inspired strategies towards the discovery of novel bioactive molecules
Schematic representation of the concept of biology-oriented synthesis depicting scaffold-substituent analogy between small molecules and protein adapted from ref. 44 (https://doi.org/10.1002/anie.201007004) with permission). (The small-molecule scaffold determines the spatial orientation of the substituents, whereas the protein subfold arranges the amino acid side chains spatially. Binding occurs when compatible substituents match in their spatial positioning so they can interact.)