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Table 3 Effect of Paederia foetida whole plant extract (200, 400 mg/kg/day, p.o., for 4 weeks) on serum sodium value, in Amphetamine-induced hypertensive rats and taking Hydralazine as a standard

From: Unveiling geniposide from Paederia foetida as a potential antihypertensive treatment: an integrated approach involving in vivo and computational methods

Treatment groups(mg/kg)

Serum Na + (mMol/ml)

1st week

2nd week

3rd week

4th week

Control

152.23 ± 0.18*

152.47 ± 0.19*

153 ± 0.27*

153.42 ± 0.44*

Amphetamine (5)

151.40 ± 0.48*

150.85 ± 0.44*

149.85 ± 0.97*

148.83 ± 0.46*

Amphetamine (5) + Paederia foetida (P.F.) (200)

151.31 ± 0.30*

151.55 ± 0.48*

151.81 ± 0.22*

151.29 ± 0.37*

Amphetamine (5) + Paederia foetida (P.F.) (400)

151.39 ± 0.89*

151.66 ± 0.55*

151.96 ± 0.87*

152.09 ± 0.17*

Amphetamine (5) + Hydralazine (25)

152 ± 0.02*

152.11 ± 0.69*

152.11 ± 0.88*

154.84 ± 0.54*

  1. Values are expressed as mean ± std, n = 6. Differences were considered significant at *P value of < 0.05. For numerical results, analysis of variance (ANOVA) was performed using GraphPad InStat version 3
  2. *indicates level of significance