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Table 7 Effect of formulation development coefficients

From: A Design of Experiment (DoE) based approach for development and optimization of nanosuspensions of telmisartan, a BCS class II antihypertensive drug

Effect of coefficients on particle size

Term

Coefficient estimate

df

Standard error

95% CI low

95% CI high

VIF

Intercept

347.74

1

0.85

345.72

349.76

 

A-HPMC

− 8.06

1

0.85

− 10.08

− 6.04

1.00

B-Speed

39.51

1

0.85

37.49

41.53

1.00

Effect of coefficients on percentage cumulative drug release

Intercept

95.86

1

0.38

94.96

96.76

 

A-HPMC

4.84

1

0.38

3.94

5.74

1.00

B-Speed

− 2.01

1

0.38

− 2.91

− 1.11

1.00