Skip to main content
Future Journal of Pharmaceutical Sciences

Table 2 Olanzapine-induced gene set enrichment analysis in Homo sapiens, Rattus norvegicus, Mus musculus, and Danio rerio

From: Zebrafish shares common metabolic pathways with mammalian olanzapine-induced obesity

Organism

Pathway

Description

Gene count

Genes

False discovery rate

Homo sapiens

hsa04975

Fat digestion and absorption

2

FABP1, BCA1

0.0428

hsa04931

Insulin resistance

3

SLC2A1,SLC2A4, NR1H2

0.0428

hsa04920

Adipocytokine signaling pathway

3

SLC2A1,SLC2A4, ADIPOQ

0.0428

hsa04152

AMPK signaling pathway

3

SLC2A4, ADIPOQ, HMGCR

0.0428

hsa01100

Metabolic pathways

9

ALDH18A1, DHFR, H6PD, LSS, SC5D, HMGCS1, CYP2E1, HMGCR, ASAH1

0.0428

hsa00900

Terpenoid backbone biosynthesis

2

HMGCS1, HMGCR

0.0428

hsa00100

Steroid biosynthesis

2

LSS, SC5D

0.0428

hsa04930

Type II diabetes mellitus

2

SLC2A4, ADIPOQ

0.0482

Rattus norvegicus

rno04920

Adipocytokine signaling pathway

3

Adipoq, Slc2a4

0.0222

rno04931

Insulin resistance

3

Slc2a4, Nr1h2

0.0242

rno04152

AMPK signaling pathway

3

Adipoq, Slc2a4

0.0242

rno01100

Metabolic pathways

8

Cyp2e1, Hmgcr, Sc5d, Hmgcs1, Lss, H6pd, Dhfr, Asah1

0.0242

rno00900

Terpenoid backbone biosynthesis

2

Hmgcr, Hmgcs1

0.0242

rno00100

Steroid biosynthesis

2

Sc5d, Lss

0.0242

rno04975

Fat digestion and absorption

2

Fabp1, Abca1

0.0251

rno04930

Type II diabetes mellitus

2

Adipoq, Slc2a4

0.0315

rno04510

Focal adhesion

3

Vtn, Tnc

0.0428

Mus musculus

mmu04975

Fat digestion and absorption

2

Abca1, Fabp1

0.0283

mmu04931

Insulin resistance

3

Nr1h2, Slc2a4, lc2a1

0.0283

mmu04920

Adipocytokine signaling pathway

3

Adipoq, Slc2a4, Slc2a1

0.0283

mmu04152

AMPK signaling pathway

3

Adipoq, Slc2a4, Hmgcr

0.0283

mmu01100

Metabolic pathways

9

Asah1, Cyp2e1, H6pd, Hmgcr, Dhfr, Aldh18a1, Hmgcs1, Lss, Sc5d

0.0283

mmu00900

Terpenoid backbone biosynthesis

2

Hmgcs1, Hmgcr

0.0283

mmu00100

Steroid biosynthesis

2

Sc5d, Lss

0.0283

mmu04930

Type II diabetes mellitus

2

Adipoq, Slc2a4

0.0374

Danio rerio

dre00100

Steroid biosynthesis

2

sc5d, lss

0.0114

dre01100

Metabolic pathways

7

sc5d, hmgcs1, lss, h6pd, dhfr, aldh18a1, asah1a

0.0320

dre04510

Focal adhesion

3

fynb, tnc, rapgef1b

0.0453

Back to article page