In situ gel drug delivery system for periodontitis: an insight review

Future Journal of Pharmaceutical Sciences

Table 3 Various principle and targets in LOC platforms, paper-based platforms, and chairside platforms for periodontitis diagnosis

Classification	Principle	Sample	Targets	References
LOC platforms	Electrophoretic immunoassays	Saliva	C-reactive protein	[41]
			IL-6
			TNF-∝
	Sandwich ELISA	Saliva	C-reactive protein	[42]
			MMP-8
			IL-1β
	PCR	Bacterial culture	Pi	[43]
			Aa
			Pg
			Td
	Sandwich ELISA	GCF	Calprotectin	[44]
Paper-based POCT platforms	Sandwich ELISA	Subgingival plaque	Pg	[45]
	Sandwich ELISA	GCF	MMP-8	[46]
	Sandwich ELISA	Saliva	Pg	[47]
	Sandwich ELISA	Saliva	MMP-8	[48]
	Sandwich ELISA	Saliva	MMP-8	[49]
	Sandwich ELISA	Saliva	MMP-9	[49]
	Modified Griess reaction	Saliva	Nitrite	[50]
	Proteolytic reaction	Saliva	Pg	[51]
	Proteolytic reaction	Saliva	Neutrophil elastase	[52]
	Proteolytic reaction	Saliva	Cathepsin-G	[52]
Chairside platforms	DNA hybridization	Laboratory and clinical specimens	Aa, Pg	[53]
Microbiological	Sandwich enzyme immunoassay	Subgingival samples	Aa, Pg, Pi	[53, 54]
	BANA hydrolysis reaction	Subgingival plaque	Pg, Td	[53]
	DNA hybridization	Microbiological samples	Aa, Pg, Td, Tf	[53]
	Chemical reactions	GCF	Bacterial toxins and proteins	[53]
Biochemical	Enzymatic digestion reaction	GCF	Neutral proteases	[53]
	Enzymatic catalysis reaction	GCF	AST	[53, 55]
	Sandwich enzyme immunoassay	GCF, saliva	Various related bacterial	[56]