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Future Journal of Pharmaceutical Sciences
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Natural therapeutics for urinary tract infections—a review

Future Journal of Pharmaceutical Sciences volume 6, Article number: 64 (2020) Cite this article

Abstract

Background

The recurrence of the urinary tract infections (UTI), following the antibiotic treatments suggests the pathogen’s resistance to conventional antibiotics. This calls for the exploration of an alternative therapy.

Main body

The anti-uropathogenic and bactericidal activity of many plant extracts was reported by many researchers, which involves only preliminary antibacterial studies using different basic techniques like disk diffusion, agar well diffusion, or minimum inhibitory concentration (MIC) of the crude plant extracts, but reports on the specific action of the phytoconstituents against uropathogens are limited. Vaccinium macrocarpon Aiton (cranberry) is the best-studied home remedy for UTI. Some evidences suggest that proanthocyanins present in cranberry, prevent bacteria from adhering to the walls of the urinary tract, subsequently blocking the further steps of uropathogenesis. Probiotics such as Lactobacillus and Bifidobacterium are beneficial microorganisms that may act by the competitive exclusion principle to defend against infections in the urogenital tracts. Reports on potential vaccine agents and antibodies targeting the different toxins and effecter proteins are still obscure except uropathogenic E. coli.

Conclusion

This review highlights some of the medicinal herbs used by aborigines to prevent or treat acute or chronic urinary tract infections, botanicals with established urobactericidal activity, clinical trials undertaken to compare the efficacy of cranberry products in UTI prevention, and other natural therapeutics reported for UTI.

Background

Urinary tract infection (UTI) is a condition when any part of the urinary tract (urethra, bladder, ureter, and kidney) gets infected with bacteria or occasionally with fungus that evades the host defense barrier and colonize the urinary tract. The effect of UTI ranges from a mild self-limiting sickness to acute sepsis, with a mortality rate of 20-40% [1], which increases inexplicably with age. Both the sexes are prone to develop UTI with a female to male ratio of 2:1 in patients older than 70 years as compared to a 50:1 ratio in younger population [2]. It is the second most common infection after respiratory tract infections. Different methods are practiced to treat and prevent chronic and recurrent UTI, i.e., taking antibiotics, bioactive natural foods, using probiotics, and maintaining good personal hygiene, but still, they are yet to be addressed successfully. As UTI is generally caused by bacteria, they are most frequently treated with antibiotics. But, the type of medication and length of treatment depends on type of bacteria, its level of susceptibility, history, symptoms, and immune status of the patient.

It is not known, what percentage of people are now using alternative therapies, but certainly large numbers of women are drinking cranberry juice or using herbal remedies to enhance their immune status or taking probiotics to restore the normal vaginal flora, which usually gets disturbed after an antibiotic therapy. Vaccine development for organisms other than E. coli still remains obscure [3]. Cranberry, mannose, and probiotics are frequently used for recurrent UTI, and berberine and uva ursi are prescribed for acute UTI. Potassium salt supplements reduce dysuria by alkalinizing the urine. Application of estriol cream and supplement of vitamins A and C were considered to be effective to prevent UTI [4]. Generally, people drink plenty of water to flush out the infectious bacteria. Application of curd water around the urethra can help in getting rid of urinary burning sensation. This present review enlists some ethnobotanicals, which are reported to be beneficial for UTI and other urinary disorders. It covers a list of potential herbs with urobactericidal activity, the in vitro/in vivo and clinical trial studies reported to prove the efficacy of cranberry in treating UTI. It also represents the synopsis of relevant natural therapeutics, those are proven to be useful in both prevention and cure of urological disorders.

Methods

Intense review of literature on the prevalence, mechanism of urinary tract infection, risk factors, preventive measures, and natural therapeutics for UTI were carried out using different databases like Google, Pubmed, and Sciencedirect. The keywords like the preventive and therapeutic role of different plants and their products in uropathogenesis, medicinal plants for acute and recurrent UTI, natural remedies, therapeutics for UTI, and anti-uropathogenic activity of medicinal plants, role of cranberry in acute and recurrent UTI were accessed from Medline, Google, Pubmed, and from different books, electronic, and printed journals, available in the library of Berhampur University, Utkal University, Institute of Life Sciences, and Regional Medical Research Center, Bhubaneswar, Odisha. The different keywords like urinary tract infection, uropathogenic bacteria, uropathogenesis, and UPEC are used in Google, Pubmed, and www.asm.org websites. The language chosen was English and both research and review articles were taken into account.

Botanicals used for UTI

Therapeutic botanicals are defined as plants and their products with medicinal value. Indigenous plants are used for various ailments since time immemorial by mankind and probably we had learned this art from animals, since they have the inherent ability to use natural products for their different health ailments. These natural products are rich in diverse bioactive compounds, which form the basis for the development of new pharmaceuticals. There are immense advantages of using therapeutic botanicals like lesser side effects, more patient approval, less costly, and can be renewed naturally [5]. There are many reports that phytochemicals act as multi-drug resistance inhibitors/modulators that augment the effect of commonly used antibiotics [6, 7]. Diuretics like Solidago spp (goldenrod) herb, Levisticum officinale (lovage) root, Petroselinum crispus (parsley) fruit, and Urtica dioica (stinging nettle) increase urine volume in both healthy and people with urinary disorders that help in flushing out the probable threats. People, who consume antiseptic and anti-adhesive herbs like Arctostaphylos uva-ursi (uva ursi), Juniperus spp (Juniper) leaf, and fruit of Vaccinium macrocarpon (cranberry) excrete antimicrobial compounds, which may directly kill microbes or interfere with their adhesion to epithelial cells, thereby protecting against acute and chronic UTI [8]. The roots of Mahonia aquifolium (Pursh) Nutt. (Oregon grape) (Berberidaceae) and Hydrastis canadensis L. (Goldenseal) (Ranunculaceae) are rich in berberine. Berberine is an important drug against many bacteria and combat infections by preventing the bacteria (E. coli and Proteus species) from adhering to the host cell [9], which suggests their potent role in treating UTI.

Supplement of aqueous extract of corn (Zea mays L.) silk (outer thread-like part) to UTI patients significantly reduced the symptoms by reducing the number of RBCs, pus cells, and crystals in urine without any side effects [10]. It is rich in diverse therapeutic compounds [11]. Plants belonging to family Apiaceae, Fabaceae, Malvaceae followed by Asteraceae and Cucurbitaceae were found to be very effective against UTI [12]. Ethnomedicinal use of some plants against recurrent and chronic UTI is listed in Table 1.

Table 1 Directory of some important ethnomedicinal plants/plant parts used for UTI
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Botanicals with anti-uropathogenic activity

Few Jordanian plants were reported to have antibiotic resistance-modifying activity against MDR E. coli. Especially, methanol extracts of the plant parts improved the effects of cephalexin, doxycycline, neomycin, chloramphenicol, and nalidixic acid against both the standard and resistant strains of E. coli. Extracts of Anagyris foetida L. (Fabaceae) and Lepidium sativum L. (Apiaceae) had differential activity against the standard and resistant strains as it decreased the activity of amoxicillin against the standard strain but increased the activity against resistant strains. Edible plants like Gundelia tournefortii L. (Asteraceae), Eruca sativa Mill. (Brassicaceae), and Origanum syriacum L. (Lamiaceae), augmented clarithromycin activity against the resistant E. coli strain. Perhaps these antibiotics and plant extracts may be prescribed together to treat infections caused by MDR E. coli [24]. There are numerous reports for the anti-uropathogenic and urobactericidal activities of various plants and their products, which are listed in Table 2.

Table 2 List of medicinal plants with anti-uropathogenic potential
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Cranberry: a potent uroprotective agent

For centuries, cranberries have been used as a treatment for urinary tract diseases and its antibacterial activity was reported long back [60]. It contains > 80% water, 10% carbohydrates (glucose and fructose) [61], and other phytoconstituents like anthocyanins, flavonoids, terpenoids, catechins, organic acids (citric acid, malic acid, and quinic acid, etc.) with small amount of ascorbic acid, benzoic acid, glucuronic acids [62]. Quinic acid was suggested to be responsible for excretion of hippuric acid in urine in large amounts, which is an antibacterial agent and also has the ability to acidify the urine [63, 64]. Moreover, the elucidation of the UTI pathogenesis has opened a new vista to understand the mode of action of cranberry as an anti-adhesive prophylactic and therapeutic agent for UTI [65].

Escherichia coli strains isolated from urine (UPEC) attached three times more efficiently to uroepithelial cells than E. coli isolated from other experimental sources like stool, sputum, or wound. This proves a unique population of E. coli strain responsible for UTI [66]. Antiadherence activity against gram-negative bacteria isolated from urine and other medical sources was observed in volunteers administered with cranberry juice cocktail or urine and uroepithelial cells obtained after drinking the cocktail, which proves its efficacy in treating UTI [66]. Consumption of different cranberry products helped young and elderly women in preventing and protecting them against UTI [67].

The anthocyanidin/proanthocyanidin biocompounds present in cranberry are reported often to be potent antiadhesive compounds. Since cranberry inhibits the adhesion of type I and P-fimbriated uropathogens (e.g., uropathogenic E. coli) to the uroepithelium, thus, weaken colonization and succeeding infection [68]. Figure 1 depicts the molecular mechanism of antiadhesive property of proanthocyanidins. Due to lack of proper standardization of cranberry products, it becomes extremely complicated to compare products or correlate the results [69]. The in vitro and in vivo studies were summarized in Table 3.

Fig. 1
figure 1

Type 1 or P-fimbriae inhibitors (e.g., proanthocyanins) are shown as green balls interfering with binding of bacterial fimbriae to uroepithelial cell

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Table 3 In vitro/in vivo activity of cranberries against UTI causing bacteria
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The recurrence of UTI rates was reduced up to 35% in young to middle-aged women, after the use of cranberry-based compounds. But, in groups with complicated UTI (i.e., young and elderly patients, or patients with neurogenic bladder or with chronic indwelling catheters), the potency of cranberry was unclear. However, these compounds cannot be taken for a longer duration as they have some undesirable effects like weight gain, gastrointestinal problems, and harmful interactions with other drugs [69]. Clinical trials were often complicated and results are not satisfactory in patients with complicated UTI, whereas, cranberry uptake significantly prevented acute cystitis in high-risk females [88]. The clinical trials undertaken with cranberry were summarized in Table 4.

Table 4 Clinical trials of cranberry products for UTI prevention in different populations
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Cinnamom verum J. Presl. (cinnamon): a potent botanical for complicated UTI

Chronic recurrent UTI was resulted in patients with urinary catheters due to biofilm formation by MDR UPEC. Trans-cinnamaldehyde (0%, 1%, 1.25%, or 1.5%) was reported to prevent UPEC biofilm formation both on plate culture and indwelling catheters. When trans-cinnamaldehyde was used in catheter lock solution, it inactivated UPEC biofilm formation on catheters. Since the test concentrations had no cytotoxic effects on human bladder epithelial cells, it can be used as a surface coating for catheters or in catheter lock solution to prevent UTI [115]. Trans-cinnamaldehyde significantly reduced uroepithelial cell attachment and invasion by UPEC by inhibiting the expression of major genes associated with its attachment and invasion to host tissue [116]. These findings support the use of cinnamon as a natural remedy for UTI.

Arctostaphylos uva-ursi (L.) Spreng (bearberry)

Arctostaphylos uva-ursi (uva ursi), also known as bearberry or upland cranberry, is a useful herb for bladder infection. Bearberry leaves and preparations made from them have significant antibacterial activity (especially against E. coli) and astringent activity due to its arbutin content and diuretic properties. In a double-blind study of 57 women, five of twenty-seven women had a recurrence in the placebo group while none of thirty women had a recurrence in the uva ursi group after 1 year [117]. Schindler et al. reported that the total amount of urinary excretion of arbutin metabolites (hydroquinone) remained same in all the three groups, after the administration of a single oral dose of bearberry leaves extract or film-coated tablets or an aqueous solution in a randomized crossover study (n = 16) [118].

Probiotics

Probiotics are helpful in establishing and maintaining normal ecology of the vagina, urethra, and bladder and a proper bladder pH and preventing recurrent UTI, which was supported by various in vivo and in vitro studies. Lactobacilli are present predominantly in the urogenital flora of healthy reproductive-aged women. But, the flora is disturbed following long term antibiotic administration and post menstruation temporarily and in post-menopausal women permanently. Supplement of Lactobacillus rhamnosus GR-1 and Lactobacillus fermentum RC-14 appears to be most effective in reducing the risk of intestinal and urogenital infections [119]. The antagonistic activity of five probiotic lactobacilli (L. rhamnosus, L. fermentum, L. acidophilus, L. plantarum, and L. paracasei) and two bifidobacteria (Bifidobacterium lactis, B. longum) against six target pathogens were estimated using different assays. Pyelonephritic E. coli was highly suppressed by L. rhamnosus and both bifidobacterial strains [120]. One hundred thirty-nine women (mean age: 30.5 years) with acute UTI were compared with 185 women of similar age with no episodes of UTIs for 5 years. Frequent consumption of fresh juices, especially berry juices, and fermented milk products containing probiotic bacteria decreased the risk of recurrence of UTI in fertile women. So, dietary supplements can be used to prevent UTI [121].

Preincubation of the uroepithelial cells with Lactobacillus bacterial cell wall fragments inhibited the adherence and colonization of gram-negative uropathogens either completely or partially, which prevented the onset of UTI in female rats. Since the lipoteichoic acid present in the bacterial cell wall is responsible for the adherence of the Lactobacillus cells to uroepithelial cells but its steric hindrance blocked the adherence of uropathogens [122, 123]. Seven strains of lactic acid bacteria (L. paracasei, L. salivarius, two Pediococcus pentosaceus strains, two L. plantarum strains, and L. crispatus) and their fermented probiotic products exhibited clear zones of inhibition against UPEC. This suggests their potential role in adjuvant therapy for prevention and treatment of UTI. The growth of UPEC strains was significantly inhibited after co-culture with lactic acid bacteria and probiotic products in human urine. Oral administration of probiotic products also abrogated the number of viable UPEC in the urine of UPEC-challenged BALB/c mice [124].

Vaccines

Adhesin-based vaccines were very effective in blocking host–pathogen interactions, thereby preventing the establishment of disease [125,126,127]. In addition to the UPEC adhesins (i.e., pili, fimbriae), adhesins from P. mirabilis, and E. faecalis were also reported as vaccine targets [128]. Vaccination with HlyA (UPEC pore-forming toxin) reduced the rate of renal scaring compared to controls, though it could not prevent UPEC colonization of the kidneys [129]. Several urease inhibitors, i.e., acetohydroxamic acid (AHA), phosphoramidites, benzimidazoles have been used as potent drugs for UTI treatment against urease producing bacterial species like P. mirabilis and S. saprophyticus [130]. Pilicides (type 1 pilus assembly inhibitor) and mannosides (pili function inhibitor) block UPEC colonization, invasion, and biofilm formation and prevent UTI [131, 132].

Discussions

Antibiotics are frequently used to treat and prevent acute and recurrent UTI, but their repeated use can result in dysbiosis of vaginal and intestinal normal flora, as well as antibiotic resistance due to the high mutation ability and horizontal gene transfer capability of different pathogens. Moreover, different mechanisms are used by uropathogens for survival in the bladder under stresses such as starvation and immune responses. Uropathogens undergo morphological changes, invade uroepithelial cells, and form biofilms to persist and cause recurrent infections. Extracellular DNA, exopolysaccharides, pili, flagella, and other adhesive fibers create a niche for a bacterial community that is secluded from antimicrobial agents, immune responses, and other stresses [133]. Thus, it is high time to seek alternative methods for the prevention and treatment of UTIs.

Diuretic botanicals like Asparagus officinalis L. (asparagus), Betula spp. (birch) Elymus repens (L.) Gould (synonym: Agropyron repens) (couch grass), Solidago virgaurea L. (goldenrod), and Equisetum arvense L. (horsetail) work against UTI by increasing urinary volume and supposedly flushing bacteria out of the urinary tract. Ayurvedic herbs like Tribulus terrestris L., Boerhavia diffusa L., Tinospora cordifolia (Willd.) Miers, and Santalum album L. are used since time immemorial for UTI in India. The tribes of Odisha state, India, use the roots of Adiantum lunulatum Burm. f, Argemone mexicana L., Clausena excavata Burm. f, Mimosa pudica L., epicarp of Cucumis melo L., and seeds of Cucumis sativus L. for UTIs. These herbs have proven anti-uropathogenic activities, which were reported enormously by different researchers. However, reports on anti-uropathogenic activity of specific phytoconstituents or their mode of action at the molecular level on uropathogens like enzyme or protein inhibition or degradation, cell membrane, or cell wall disruption or dysfunction of other vital organs of uropathogens are limited. Though the herbal remedies are considered safe to use without any significant side effects yet they are slow in action to be effective in serious acute infections, but they are more effective in preventing recurrence and safeguarding against the post-infectious sequelae.

The safety and efficacy of a product containing two probiotic strains of Lactobacilli plus cranberry extract was reported for impeding recurrent UTIs in pre-menopausal adult women. After 26 weeks, in a randomized, double-blind, placebo-controlled pilot study, a significantly lower number of women experienced recurrent UTIs (9.1 vs 33.3%), those who were administered with the product as compared to placebo [134]. In another study, the efficacy and safety of standardized cranberry capsules as prophylaxis in children with recurrent UTI was reported, where children on cranberry compared to the control group experienced significantly lower percentage of recurrent UTIs, with no side effects. A declined trend of E. coli infections was observed in the cranberry group (83.3% vs. 66.6%), though it was not significant (p = 0.28) [135].

Root extract of Hemidesmus indicus R. Br. (Indian sarsaparilla) (Asclepiadaceae) and seed extract of P. granatum (pomegranate) were reported to have urobactericidal activity against different uropathogens, clinically isolated from patients suffering from urinary tract infections, i.e., Escherichia coli, Enterococcus faecalis, Staphylococcus aureus, and Klebsiella pneumonia [59, 136, 137]. Along with the presence of therapeutic antioxidants, i.e., phenolic compounds, tannins, steroids, terpenes, coumarins, and flavonoids, the extracts were found to be rich in natural glycosides, which are supposed to act as molecular decoys to prevent adhesion of pathogenic bacteria to host cell, thereby inhibiting the future pathogenesis. However, further research is required to confirm it. Till date, there are many reports on scientific evaluations and clinical trials of natural therapeutics for UTI, but they have serious limitations in study design and data interpretation. Most of the products mentioned in this review are based on “in vitro” studies; therefore, more clinical trials should be undertaken in order to assess the efficacy of these alternative preventions and therapeutic methods in humans.

Conclusion

Uroprotective role of cranberry was reported by maximum researchers, yet they suffer from serious drawbacks and fail to prove that cranberry use can prevent or treat acute and recurrent UTI. So, further investigation should focus on the molecular action of various phytochemicals present in cranberry and other potential berries against different uropathogens and uropathogenesis. Supplementation of probiotics was also proven to be effective in both acute and recurrent UTI. However, scientific validation with efficient clinical trial reports will strengthen the practice of using these traditional resources, which will help us in preventing these common yet very discomforting ailments.

Availability of data and materials

All data generated or analyzed during this study are included in this published article.

Abbreviations

MIC:

Minimum inhibitory concentration

MDR:

Multidrug resistant

PAC:

Proanthocyanidine

UTI:

Urinary tract infection

UPEC:

Uropathogenic Escherichia coli

References

  1. Wagenlehner FM, Lichtenstern C, Rolfes C, Mayer K, Uhle F, Weidner W, Weigand MA (2013) Diagnosis and management for urosepsis. Int J Urol 20:963–970

    PubMed  Google Scholar 

  2. Cove-Smith A, Almond MK (2007) Management of urinary tract infections in the elderly. Trends in Urology Gynaecol Sex Health 12:31–34

    Google Scholar 

  3. Reid G (1999) Potential preventive strategies and therapies in urinary tract infection. World J Urol 17(6):359–363

    CAS  PubMed  Google Scholar 

  4. Head KA (2008) Natural approaches to prevention and treatment of infections of the lower urinary tract. Altern Med Rev 13(3):227–244

    PubMed  Google Scholar 

  5. Gur S, Turgut-Balik D, Gur N (2006) Antimicrobial activities and some fatty acids of turmeric, ginger root and linseed used in the treatment of infectious diseases. World J Agricultural Sci 2:439–442

    Google Scholar 

  6. Ahmad I, Aqil F (2007) In vitro efficacy of bioactive extracts of 15 medicinal plants against ESβL-producing multidrug-resistant enteric bacteria. Microbiol Res 162:264–275

    PubMed  Google Scholar 

  7. Sibanda T, Okoh AI (2008) In vitro evaluation of the interactions between acetone extracts of Garcinia kola seeds and some antibiotics. Afr J Biotechnol 7:1672–1678

    Google Scholar 

  8. Yarnell E (2002) Botanical medicines for the urinary tract. World J Urol 20(5):285–293

    PubMed  Google Scholar 

  9. Amin AH, Subbaiah TV, Abbasi KM (1969) Berberine sulfate: antimicrobial activity, bioassay, and mode of action. Can J Microbiol 15(9):1067–1076

    CAS  PubMed  Google Scholar 

  10. Sahib AS, Mohammed IH, Hamdan SJ (2012) Use of aqueous extract of corn silk in the treatment of urinary tract infection. J Intercult Ethnopharmacol 1(2):93–96

    Google Scholar 

  11. Wang GQ, Xu T, Bu XM, Liu BY (2012) Anti-inflammation effects of corn silk in a rat model of carrageenin induced pleurisy. Inflammation 35(3):822–827

    PubMed  Google Scholar 

  12. Pattanayak S, Das DC, Sinha NK, Parida S (2017) Use of medicinal plants for the treatment of urinary tract infections: a study from Paschim Medinipur district, West Bengal, India. Int J Pharm Bio Sci 8(3):250–259

    Google Scholar 

  13. Girach RD (1992) Medicinal plants used by Kondha tribe of district Phulbani (Orissa) in eastern India. Ethnobot 4:53–66

    Google Scholar 

  14. Nayak A, Das NB, Nanda B (1998) Utility of some tribal drugs of Keonjhar and Similipal area. JTR Chem 5(2):53–59

    CAS  Google Scholar 

  15. Brahmam M, Dhal NK, Saxena HO (1996) Ethnobotanical studies among the Tanla of Malyagiri hills in Dhenkanal district Odisha, India. In: Jain SK (ed) Ethnobiology in Human welfare. Deep publication, New Delhi, pp 393–396

    Google Scholar 

  16. Satapathy KB, Brahmam M (1996) Some medicinal plants used by the tribals of Sundargarh district, Orissa, India. In: Jain SK (ed) Ethnobiology in Human welfare. Deep publications, New Delhi, pp 153–158

    Google Scholar 

  17. Aminuddin GRD (1993) Observations of the ethnobotany of the Bhunjia – a tribe of Sonabera plateau. Ethnobot 5:83–86

    Google Scholar 

  18. Girach RD, Aminuddin AM, Mishra MK (1996) Native phytotherapy among rural population of district Bhadrak, Orissa. In: Jain SK (ed) Ethnobiology in human welfare. Deep publications, New Delhi, pp 162–164

    Google Scholar 

  19. Dash SS, Mishra MK (1999) Plant diversity and sustainable development in a tribal village eco-complex on the eastern ghats of Odisha. J Hum Ecol 10(5-6):415–419

    Google Scholar 

  20. Bhattarai S, Chaudhary RP, Taylor RSL, Ghimire SK (2009) Biological activities of some Nepalese medicinal plants used in treating bacterial infections in human beings. Nepal J Sci Tech 10:83–90

    Google Scholar 

  21. Prachi CN, Kumar D, Kasana MS (2009) Medicinal plants of Muzaffarnagar district used in treatment of urinary tract and kidney stones. Ind J Trad Med 8(2):191–195

    Google Scholar 

  22. Hossan MS, Hanif A, Agarwala B, Sarwar MS, Karim M, Rahman MTU, Jahan R, Rahmatullah M (2010) Traditional use of medicinal plants in Bangladesh to treat urinary tract infections and sexually transmitted diseases. Ethnobot Res Appl 8:61–74

    Google Scholar 

  23. Revathi P, Parimelazhagan T (2010) Traditional knowledge on medicinal plants used by the Irula tribe of Hasanur hills, Erode district, Tamil Nadu, India. Ethnobot Leaflets 2:4

    Google Scholar 

  24. Darwish RM, Aburjai TA (2010) Effect of ethnomedicinal plants used in folklore medicine in Jordan as antibiotic resistant inhibitors on Escherichia coli. BMC Complement Altern Med 10:9–16

    PubMed  PubMed Central  Google Scholar 

  25. Pereiraa RS, Sumitaa TC, Furlanb MR, Jorgec AOC, Uenod M (2004) Antibacterial activity of essential oils on microorganisms isolated from urinary tract infection. Rev Saude Publica 38(2):1–3

    Google Scholar 

  26. Sowmiya S, Soundarapandian P, Rajan S (2009) Bioactive studies of Mangifera indica against bacteria isolated from urine samples. Curr Res J Biol Sci 1(3):139–143

    Google Scholar 

  27. Sharma A, Chandraker S, Patel VK, Ramteke P (2009) Antibacterial activity of medicinal plants against pathogens causing complicated urinary tract infections. Indian J Pharm Sci 71(2):136–139

    PubMed  PubMed Central  Google Scholar 

  28. Nweze EI, Eze EE (2009) Justification for the use of Ocimum gratissimum L. in herbal medicine and its interaction with disc antibiotics. BMC Complement Altern Med 9:37

    PubMed  PubMed Central  Google Scholar 

  29. Yushau M, Onuorah FC, Murtala Y (2009) In-vitro sensitivity pattern of some urinary tract isolates to Carica papaya extracts. Bayero J Pure Appl Sci 2(2):75–78

    Google Scholar 

  30. Sosa V, Zunino P (2009) Effect of Ibicella lutea on uropathogenic Proteus mirabilis growth, virulence, and biofilm formation. J Infect Dev Countries 3(10):762–770

    Google Scholar 

  31. Kumar A, Sharma VK (2010) Antibacterial activity of allicin from Allium sativum against antibiotic resistant uropathogens. Int J Infect Dis 8(1)

  32. Ravikumar S, Gnanadesigan M, Suganthi P, Ramalakshmi A (2010) Antibacterial potential of chosen mangrove plants against isolated urinary tract infectious bacterial pathogens. Int J Med Medical Sci 2(3):94–99

    Google Scholar 

  33. Poovendran P, Vidhya N, Murugan S (2011) Antimicrobial activity of Coccinia grandis against biofilm and ESBL producing uropathogenic E. coli. Global J Pharmacol 5(1):23–26

    Google Scholar 

  34. Khare RS, Karmakar S, Banerjee S, Nath G, Kundu S, Kundu K (2011) Uropathogen resistant essential oils of Coleus aromaticus and Ocimum sanctum. Int J Pharm Sci Res 2(8):2168–2172

    CAS  Google Scholar 

  35. Balasundaram A, Rathna Kumari P, John G, Selvakumar BN (2011) Antimicrobial activity of the leaf extracts of two medicinal plants against MRSA (Methicilin resistant Staphylococcus aureus) from human urinary tract pathogens. Res J Microbiol 6(7):625–631

    Google Scholar 

  36. Arun T, Rao CHP (2011) Phytochemical screening and antibacterial activity of Moringa oleifera Lam. against Proteus mirabilis from urinary tract infected patients. Int J Pharm Tech Res 3(4):2118–2123

    CAS  Google Scholar 

  37. Narayanan AS, Raja SS, Ponmurugan K, Kandekar SC, Natarajaseenivasan K, Maripandi A, Mandeel QA (2011) Antibacterial activity of selected medicinal plants against multiple antibiotic resistant uropathogens: a study from Kolli Hills, Tamil Nadu, India. Benefic Microbes 2(3):235–243

    CAS  Google Scholar 

  38. Vogel NW, Taschetto AP, Dallagnol R, Weidlich L, Ethur EM (2011) Assessment of the antimicrobial effect of three plants used for therapy of community-acquired urinary tract infection in Rio Grande do Sul (Brazil). J Ethnopharmacol 137(3):1334–1336

    CAS  PubMed  Google Scholar 

  39. Khan MS, Ahmad I (2012) Biofilm inhibition by Cymbopogon citratus and Syzygium aromaticum essential oils in the strains of Candida albicans. J Ethnopharmacol 140(2):416–423

    CAS  PubMed  Google Scholar 

  40. Kannan RR, Arumugam R, Anantharaman P (2012) Chemical composition and antibacterial activity of Indian seagrasses against urinary tract pathogens. Food Chem 135(4):2470–2473

    Google Scholar 

  41. Wojnicz D, Kucharska AZ, Sokol-Lętowska A, Kicia M, Tichaczek-Goska D (2012) Medicinal plants extracts affect virulence factors expression and biofilm formation by the uropathogenic Escherichia coli. Urol Res 40(6):683–697

    PubMed  PubMed Central  Google Scholar 

  42. Reygaert W, Jusufi I (2013) Green tea as an effective antimicrobial for urinary tract infections caused by Escherichia coli. Front Microbiol 4:162

    PubMed  PubMed Central  Google Scholar 

  43. Jagadeesan S, Natarajan V, Rajitha E, Vijayan S, Singaram S (2013) Antibacterial activity of selective plant extracts against urinary tract infection causing organisms. J Microbiol Biotech Res 3(3):1–5

    Google Scholar 

  44. Rawat S, Ishaq F, Khan A (2013) Antimicrobial effect of drugs, medicinal plant extracts and essential oils against pathogenic bacteria causing urinary tract infection. Global J Biotech Biochem 8(1):15–24

    Google Scholar 

  45. Poongothai P, Rajan S (2013) Antibacterial properties of Mangifera indica flower extracts on uropathogenic Escherichia coli. Int J Curr Microbiol App Sci 2(12):104–111

    Google Scholar 

  46. Manasa M, Kambar Y, Swamy HCS, Vivek MN, Kumar TNR, Kekuda TRP (2013) Antibacterial efficacy of Pimenta dioica (Linn.) Merill and Anacardium occidentale L. against drug resistant urinary tract pathogens. J Appl Pharmaceut Sci 3(12):72–74

    Google Scholar 

  47. Nadir M, Rasheed M, Sherwani SK, Kazmi SU, Ahmad VU (2013) Chemical and antimicrobial studies on the essential oil from Salvia santolinifolia Boiss. Pak J Pharm Sci 26(1):39–52

    CAS  PubMed  Google Scholar 

  48. Rafsanjany N, Lechtenberg M, Petereit F, Hensel A (2013) Antiadhesion as a functional concept for protection against uropathogenic Escherichia coli: In vitro studies with traditionally used plants with antiadhesive activity against uropathognic Escherichia coli. J Ethnopharmacol 145(2:591–597

    Google Scholar 

  49. Dhanalakshmi J, Selvi S (2013) Antibacterial activity of medicinal plants used against UTI (urinary tract infection) causing pathogens. Int J Res Sci 1(1):01–07

    Google Scholar 

  50. Noormandi A, Dabaghzadeh F (2014) Effects of green tea on Escherichia coli as a uropathogen. J Tradit Complement Med 5(1):15–20

    PubMed  PubMed Central  Google Scholar 

  51. Kavitha KS, Satish S (2014) Antibacterial activity of seed extracts of Callistemon lanceolatus DC on uropathogenic bacteria. J Acute Med 4(1):6–12

    Google Scholar 

  52. Vivek MN, Manasa M, Pallavi S, Swamy HCS, Kumar TNR, Kekuda TRP (2014) Antibacterial activity of cashew (Anacardium occidentale L.) apple juice against antibiotic resistant urinary tract pathogens. World J Pharmaceu Sci 2(1):79–82

    Google Scholar 

  53. Alshami I, Alharbi AE (2014) Hibiscus sabdariffa extract inhibits in vitro biofilm formation capacity of Candida albicans isolated from recurrent urinary tract infections. Asian Pac J Trop Biomed 4(2):104–108

    PubMed  PubMed Central  Google Scholar 

  54. Jahan N, Khatoon R, Ahmad S (2015) Evaluation of antibacterial potential of medicinal plant Cassia sophera against organisms causing urinary tract infection. Int J Pure App Biosci 3(2):450–455

    Google Scholar 

  55. Tibyangye J, Okech MA, Nyabayo JM, Nakavuma JL (2015) In vitro antibacterial activity of Ocimum suave essential oils against uropathogens isolated from patients in selected hospitals in Bushenyi District, Uganda. British Microbiology Research Journal 8(3):489–498

    CAS  PubMed  PubMed Central  Google Scholar 

  56. Ebana RUB, Edet UO, Ekanemesang UM, Etok CA, Ikon GM, Noble MK (2016) Phytochemical screening and antimicrobial activity of three medicinal plants against urinary tract infection pathogens. Asian J Med Health 1(2):1–7

    Google Scholar 

  57. Samanta P, Sinha NK (2016) Antimicrobial activity of five traditionally used medicinal plants on bacterial infection of urinary tract. Int Res J Basic App Sci 1(2):24–28

    Google Scholar 

  58. Aziz MA, Adnan M, Rahman H, Allah EFA, Hashem A, Alqarawi AA (2017) Antibacterial activities of medicinal plants against multidrug resistant urinary tract pathogens. Pak J Bot 49(3):1185–1192

    Google Scholar 

  59. Das S, Naik P, Panda P (2017) Effect of Hemidesmus indicus R.Br. root extract on urinary tract infection causing bacteria. Int J Herbal Med 5(5):160–168

    Google Scholar 

  60. Bodel PT, Cotran R, Kass EH (1959) Cranberry juice and the antibacterial action of hippuric acid. J Lab Clin Med 54:881–888

    CAS  PubMed  Google Scholar 

  61. Lenter C (1991) Geigy scientific tables 18th Ed West Caldwell NJCIBA-Geigy.

  62. Borukh IF, Kirbaba VI, Senchuk GV (1972) Antimicrobial properties of cranberry. Vopr Pitan 31:82

    CAS  PubMed  Google Scholar 

  63. Kahn HD, Panariello VA, Saeli J, Sampson JR, Schwartz E (1967) Effect of cranberry juice on urine. J Amer Diet Assoc 51:251–254

    CAS  Google Scholar 

  64. Hamilton-Miller JMT (1994) Reduction of bacteriuria and pyuria using cranberry juice. JAMA 272:588

    CAS  PubMed  Google Scholar 

  65. Sobota AE (1984) Inhibition of bacterial adherence by cranberry juice: potential use for the treatment of urinary tract infections. J Urol 131(5):1013–1016

    CAS  PubMed  Google Scholar 

  66. Schmidt DR, Sobota AE (1988) An examination of the anti-adherence activity of cranberry juice on urinary and nonurinary bacterial isolates. Microbios 55(224-225):173–181

    CAS  PubMed  Google Scholar 

  67. Shmuely H, Ofek I, Weiss EI, Rones Z, Houri-Haddad Y (2012) Cranberry components for the therapy of infectious disease. Curr Opin Biotechnol 23(2):148–152

    CAS  PubMed  Google Scholar 

  68. Zafriri D, Ofek I, Adar R, Pocino M, Sharon N (1989) Inhibitory activity of cranberry juice on adherence of type 1 and type P fimbriated Escherichia coli to eukaryotic cells. Antimicrob Agents Chemother 33:92–98

    CAS  PubMed  PubMed Central  Google Scholar 

  69. Guay DR (2009) Cranberry and urinary tract infections. Drugs 69(7):775–807

    CAS  PubMed  Google Scholar 

  70. Howell AB, Vorsa N, Marderosian AD, Foo LY (1998) Inhibition of the adherence of P-fimbriated Escherichia coli to uroepithelial-cell surfaces by proanthocyanidin extracts from cranberries. N Engl J Med 339:1085–1086

    CAS  PubMed  Google Scholar 

  71. Howell AB, Reed JD, Krueger CG, Winterbottom R, Cunningham DG, Leahy M (2005) A-type cranberry proanthocyanidins and uropathogenic bacterial anti-adhesion activity. Phytochem 66(18):2281–2291

    CAS  Google Scholar 

  72. Greenberg JA, Sara J, Newmann MD, Howell AB (2005) Consumption of sweetened dried cranberries versus unsweetened raisins for inhibition of uropathogenic Escherichia coli adhesion in human urine: a pilot study. J Altern Complement Med 11(5):875–878

    PubMed  Google Scholar 

  73. Di Martino P, Agniel R, David K, Templer C, Gaillard JL, Denys P et al (2006) Reduction of Escherichia coli adherence to uroepithelial bladder cells after consumption of cranberry juice: a double-blind randomized placebo-controlled cross-over trial. World J Urol 24(1):21–27

    PubMed  Google Scholar 

  74. Valentova K, Stejskal D, Bednar P, Vostalova J, Cihalik C, Vecerova R et al (2007) Biosafety, antioxidant status, and metabolites in urine after consumption of dried cranberry juice in healthy women: a pilot double-blind placebo-controlled trial. J Agric Food Chem 55(8):3217–3224

    CAS  PubMed  Google Scholar 

  75. Gupta K, Chou MY, Howell A, Wobbe C, Grady R, Stapleton AE (2007) Cranberry products inhibit adherence of p-fimbriated Escherichia coli to primary cultured bladder and vaginal epithelial cells. J Urol 177(6):2357–2360

    CAS  PubMed  PubMed Central  Google Scholar 

  76. Lavigne JP, Bourg G, Combescure C, Botto H, Sotto A (2008) In-vitro and in-vivo evidence of dose-dependent decrease of uropathogenic Escherichia coli virulence after consumption of commercial Vaccinium macrocarpon (cranberry) capsules. Clin Microbiol Infect 14(4):350–355

    PubMed  PubMed Central  Google Scholar 

  77. Pinzon-Arango PA, Liu Y, Camesano TA (2009) Role of cranberry on bacterial adhesion forces and implications for Escherichia coli-uroepithelial cell attachment. J Med Food 12(2):259–270

    CAS  PubMed  Google Scholar 

  78. Lee YL, Najm WI, Owens J, Thrupp L, Baron S, Shanbrom E et al (2010) Antimicrobial activity of urine after ingestion of cranberry: a pilot study. Evid Based Complement Alternat Med 7(2):227–232

    PubMed  Google Scholar 

  79. Howell AB, Botto H, Combescure C, Blanc-Potard AB, Gausa L, Matsumoto T, Tenke P, Sotto A, Lavigne JP (2010) Dosage effect on uropathogenic Escherichia coli anti-adhesion activity in urine following consumption of cranberry powder standardized for proanthocyanidin content: a multicentric randomized double blind study. BMC Infect Dis 10:94

    PubMed  PubMed Central  Google Scholar 

  80. Lavigne JP, Vitrac X, Bernard L, Bruyere F, Sotto A (2011) Propolis can potentialise the anti-adhesion activity of proanthocyanidins on uropathogenic Escherichia coli in the prevention of recurrent urinary tract infections. BMC Res Notes 4:522–528

    CAS  PubMed  PubMed Central  Google Scholar 

  81. Rane HS, Bernardo SM, Howell AB, Lee SA (2014) Cranberry-derived proanthocyanidins prevent formation of Candida albicans biofilms in artificial urine through biofilm- and adherence-specific mechanisms. J Antimicrob Chemother 69(2):428–436

    CAS  PubMed  Google Scholar 

  82. Nicolosi D, Tempera G, Genovese C, Furneri PM (2014) Anti-adhesion activity of A2-type proanthocyanidins (a cranberry major component) on uropathogenic E. coli and P. mirabilis strains. Antibiotics (Basel) 3(2):143–154

    CAS  Google Scholar 

  83. Ulrey RK, Barksdale SM, Zhou W, van Hoek ML (2014) Cranberry proanthocyanidins have anti-biofilm properties against Pseudomonas aeruginosa. BMC Complement Altern Med 14:499

    PubMed  PubMed Central  Google Scholar 

  84. Sun J, Marais JPJ, Khoo C, LaPlante K, Vejborg RM, Givskov M, Tolker-Nielsen T, Seeram NP, Rowleya DC (2015) Cranberry (Vaccinium macrocarpon) oligosaccharides decrease biofilm formation by uropathogenic Escherichia coli. J Funct Foods 17:235–242

    CAS  PubMed  PubMed Central  Google Scholar 

  85. de Llano DG, Esteban-Fernandez A, Sanchez-Patan F, Martín-Álvarez PJ, Moreno-Arribas MV, Bartolome B (2015) Anti-adhesive activity of cranberry phenolic compounds and their microbial-derived metabolites against uropathogenic Escherichia coli in bladder epithelial cell cultures. Int J Mol Sci 16(6):12119–12130

    PubMed  PubMed Central  Google Scholar 

  86. Rafsanjany N, Senker J, Brandt S, Dobrindt U, Hensel A (2015) In vivo consumption of cranberry exerts ex vivo antiadhesive activity against fimH-dominated uropathogenic Escherichia coli: a combined in vivo, ex vivo, and in vitro study of an extract from Vaccinium macrocarpon. J Agric Food Chem 63(40):8804–8818

    CAS  PubMed  Google Scholar 

  87. Jensen HD, Struve C, Christensen SB, Krogfelt KA (2017) Cranberry juice and combinations of its organic acids are effective against experimental urinary tract infection. Front Microbiol 8:542

    PubMed  PubMed Central  Google Scholar 

  88. Cimolai N, Cimolai T (2007) The cranberry and the urinary tract. Eur J Clin Microbiol Infect Dis 26(11):767–776

    CAS  PubMed  Google Scholar 

  89. Avorn J, Monane M, Gurwitz JH, Glynn RJ, Choodnovskiy I, Lipsitz LA (1994) Reduction of bacteriuria and pyuria after ingestion of cranberry juice. JAM 271(10):751–754

    CAS  Google Scholar 

  90. Foda MM, Middlebrook PF, Gatfield CT, Potvin G, Wells G, Schillinger JF (1995) Efficacy of cranberry in prevention of urinary tract infection in a susceptible pediatric population. Can J Urol 2(1):98–102

    CAS  PubMed  Google Scholar 

  91. Walker EB, Barney DP, Mickelsen JN, Walton RJ, Mickelsen RA Jr (1997) Cranberry concentrate: UTI prophylaxis. J Fam Pract 45(2):167–168

    CAS  PubMed  Google Scholar 

  92. Schlager TA, Anderson S, Trudell J, Hendley JO (1999) Effect of cranberry juice on bacteriuria in children with neurogenic bladder receiving intermittent catheterization. J Pediatr 135(6):698–702

    CAS  PubMed  Google Scholar 

  93. Kontiokari T, Sundqvist K, Nuutinen M, Pokka T, Koskela M, Uhari M (2001) Randomised trial of cranberry-lingonberry juice and Lactobacillus GG drink for the prevention of urinary tract infections in women. BMJ 322(7302):1571

    CAS  PubMed  PubMed Central  Google Scholar 

  94. Stothers L (2002) A randomized trial to evaluate effectiveness and cost effectiveness of naturopathic cranberry products as prophylaxis against urinary tract infection in women. Can J Urol 9(3):1558–1562

    PubMed  Google Scholar 

  95. McGuinness SD, Krone R, Metz LM (2002) A double-blind, randomized, placebo-controlled trial of cranberry supplements in multiple sclerosis. J Neurosci Nursing 34(1):4–7

    Google Scholar 

  96. Waites KB, Canupp KC, Armstrong S, DeVivo MJ (2004) Effect of cranberry extract on bacteriuria and pyuria in persons with neurogenic bladder secondary to spinal cord injury. J Spinal Cord Med 27(1):35–40

    PubMed  Google Scholar 

  97. Linsenmeyer TA, Harrison B, Oakley A, Kirshblum S, Stock JA, Millis SR (2004) Evaluation of cranberry supplement for reduction of urinary tract infections in individuals with neurogenic bladders secondary to spinal cord injury. A prospective, double-blinded, placebo-controlled, crossover study. J Spinal Cord Med 27(1):29–34

    PubMed  Google Scholar 

  98. McMurdo ME, Bissett LY, Price RJ, Phillips G, Crombie IK (2005) Does ingestion of cranberry juice reduce symptomatic urinary tract infections in older people in hospital? A double-blind, placebo-controlled trial. Age Ageing 34(3):256–261

    PubMed  Google Scholar 

  99. Lee BB, Haran MJ, Hunt LM, Simpson JM, Marial O, Rutkowski SB et al (2007) Spinal-injured neuropathic bladder antisepsis (SINBA) trial. Spinal Cord 45(8):542–550

    CAS  PubMed  Google Scholar 

  100. Wing DA, Rumney PJ, Preslicka CW, Chung JH (2008) Daily cranberry juice for the prevention of asymptomatic bacteriuria in pregnancy: a randomized, controlled pilot study. J Urol 180(4):1367–1372

    PubMed  PubMed Central  Google Scholar 

  101. Hess MJ, Hess PE, Sullivan MR, Nee M, Yalla SV (2008) Evaluation of cranberry tablets for the prevention of urinary tract infections in spinal cord injured patients with neurogenic bladder. Spinal Cord 46(9):622–626

    CAS  PubMed  Google Scholar 

  102. McMurdo ME, Argo I, Phillips G, Daly F, Davey P (2009) Cranberry or trimethoprim for the prevention of recurrent urinary tract infections? A randomized controlled trial in older women. J Antimicrob Chemother 63(2):389–395

    CAS  PubMed  Google Scholar 

  103. Ferrara P, Romaniello L, Vitelli O, Gatto A, Serva M, Cataldi L (2009) Cranberry juice for the prevention of recurrent urinary tract infections: a randomized controlled trial in children. Scand J Urol Nephrol 43(5):369–372

    PubMed  Google Scholar 

  104. Barbosa-Cesnik C, Brown MB, Buxton M, Zhang L, DeBusscher J, Foxman B (2011) Cranberry juice fails to prevent recurrent urinary tract infection: results from a randomized placebo-controlled trial. Clin Infect Dis 52(1):23–30

    PubMed  PubMed Central  Google Scholar 

  105. Salo J, Uhar M, Helminen M, Korppi M, Nieminen T, Pokka T, Kontiokari T (2012) Cranberry juice for the prevention of recurrences of urinary tract infections in children: a randomized placebo-controlled trial. Clin Infect Dis 54(3):340–346

    PubMed  Google Scholar 

  106. Bonetta A, Di Pierro F (2012) Enteric-coated, highly standardized cranberry extract reduces risk of UTIs and urinary symptoms during radiotherapy for prostate carcinoma. Cancer Manag Res 4:281–286

    PubMed  PubMed Central  Google Scholar 

  107. Stapleton AE, Dziura J, Hooton TM, Cox ME, Yarovaya YY, Chen S, Gupta K (2012) Recurrent urinary tract infection and urinary Escherichia coli in women ingesting cranberry juice daily: a randomized controlled trial. Mayo Clin Proc 87(2):143–150

    PubMed  PubMed Central  Google Scholar 

  108. Bianco L, Perrelli E, Towle V, Ness PHV, Mehta MJ (2012) Pilot randomized controlled dosing study of cranberry capsules for reduction of bacteriuria plus pyuria in female nursing home residents. J Am Geriatr Soc 60(6):1180–1181

    PubMed  PubMed Central  Google Scholar 

  109. Burleigh AE, Benck SM, McAchran SE, Reed JD, Krueger CG, Hopkins WJ (2013) Consumption of sweetened, dried cranberries may reduce urinary tract infection incidence in susceptible women – a modified observational study. Nutr J 12:139

    PubMed  PubMed Central  Google Scholar 

  110. Caljouw MAA, van den Hout WB, Putter H, Achterberg WP, Cools HJM, Gussekloo J (2014) Effectiveness of cranberry capsules to prevent urinary tract infections in vulnerable older persons: a double-blind randomized placebo-controlled trial in long-term care facilities. J Am Geriatr Soc 62(1):103–110

    PubMed  Google Scholar 

  111. Foxman B, Cronenwett AE, Spino C, Berger MB, Morgan DM (2015) Cranberry juice capsules and urinary tract infection after surgery: results of a randomized trial. Am J Obstet Gynecol 213(2):194

    PubMed  PubMed Central  Google Scholar 

  112. Dieter AA (2015) Cranberry capsules (2 taken twice daily for an average 38 days) reduce the risk of postoperative urinary tract infection in women undergoing benign gynaecological surgery involving intraoperative catheterisation. Evid Based Med 20(4):137

    PubMed  Google Scholar 

  113. Vostalova J, Vidlar A, Simanek V, Galandakova A, Kosina P, Vacek J, Vrbkova J, Zimmermann BF, Ulrichova J, Student V (2015) Are high proanthocyanidins key to Cranberry efficacy in the prevention of recurrent urinary tract infection? Phytother Res 10:1559–1567

    Google Scholar 

  114. Maki KC, Kaspar KL, Khoo C, Derrig LH, Schild AL, Gupta K (2016) Consumption of a cranberry juice beverage lowered the number of clinical urinary tract infection episodes in women with a recent history of urinary tract infection. Am J Clin Nutr 103:1434–1442

    CAS  PubMed  Google Scholar 

  115. Amalaradjou MA, Narayanan A, Baskaran SA, Venkitanarayanan K (2010) Antibiofilm effect of trans-cinnamaldehyde on uropathogenic Escherichia coli. J Urol 184(1):358–363

    CAS  PubMed  Google Scholar 

  116. Amalaradjou MA, Narayanan A, Venkitanarayanan K (2011) Trans-cinnamaldehyde decreases attachment and invasion of uropathogenic Escherichia coli in urinary tract epithelial cells by modulating virulence gene expression. J Urol 185(4):1526–1531

    CAS  PubMed  Google Scholar 

  117. Ofek I, Goldhar J, Zafriri D, Lis H, Adar R, Sharon N (1991) Anti-Escherichia coli activity of cranberry and blueberry juices. NEJM 324:1599

    CAS  PubMed  Google Scholar 

  118. Schindler G, Patzak U, Brinkhaus B, von Niecieck A, Wittig J, Krahmer N, Glockl I, Veit M (2002) Urinary excretion and metabolism of arbutin after oral administration of Arctostaphylos uvae ursi extract as film-coated tablets and aqueous solution in healthy humans. J Clin Pharmacol 42(8):920–927

    CAS  PubMed  Google Scholar 

  119. Reid G, Bruce AW, Fraser N, Heinemann C, Owen J, Henning B (2001) Oral probiotics can resolve urogenital infections. FEMS Immunol Med Microbiol 30:49–52

    CAS  PubMed  Google Scholar 

  120. Hutt P, Shchepetova J, Loivukene K, Kullisaar T, Mikelsaar M (2006) Antagonistic activity of probiotic lactobacilli and bifidobacteria against entero and uropathogens. J Appl Microbiol 100(6):1324–1332

    CAS  PubMed  Google Scholar 

  121. Kontiokari T, Laitinen J, Jarvi L, Pokka T, Sundqvist K, Uhari M (2003) Dietary factors protecting women from urinary tract infection. Am J Clin Nutr 77:600–604

    CAS  PubMed  Google Scholar 

  122. Chan RCY, Reid G, Irvin RT, Bruce AW, Costerton JW (1985) Competitive exclusion of uropathogens from human uroepithelial cells by Lactobacillus whole cells and cell wall fragments. Infect Immun 47(1):84–89

    CAS  PubMed  PubMed Central  Google Scholar 

  123. Reid G, Chan RC, Bruce AW, Costerton JW (1985) Prevention of urinary tract infection in rats with an indigenous Lactobacillus casei strain. Infect Immun 49(2):320–324

    CAS  PubMed  PubMed Central  Google Scholar 

  124. Liu YH, Ho CY, Huang CC, Tsai CC (2016) Inhibitory effect of lactic acid bacteria on uropathogenic Escherichia coli-induced urinary tract infections. J Prob Health 4(2):144–150

    Google Scholar 

  125. Langermann S, Palaszynski S, Barnhart M, Auguste G, Pinkner JS, Burlein J, Barren P, Koenig S, Leath S, Jones CH, Hultgren SJ (1997) Prevention of mucosal Escherichia coli infection by FimH-adhesin-based systemic vaccination. Science 276:607–611

    CAS  PubMed  Google Scholar 

  126. Langermann S, Möllby R, Burlein JE, Palaszynski SR, Auguste CG, DeFusco A et al (2000) Vaccination with FimH adhesin protects cynomolgus monkeys from colonization and infection by uropathogenic Escherichia coli. J Infect Dis 181:774–778

    CAS  PubMed  Google Scholar 

  127. Asadi Karam MR, Oloomi M, Mahdavi M, Habibi M, Bouzari S (2013) Vaccination with recombinant FimH fused with flagellin enhances cellular and humoral immunity against urinary tract infection in mice. Vaccine 31:1210–1216

    CAS  PubMed  Google Scholar 

  128. Li X, Erbe JL, Lockatell CV, Johnson DE, Jobling MG, Holmes RK, Mobley HLT (2004) Use of translational fusion of the MrpH fimbrial adhesin-binding domain with the cholera toxin A2 domain, coexpressed with the cholera toxin B subunit, as an intranasal vaccine to prevent experimental urinary tract infection by Proteus mirabilis. Infect Immun 72:7306–7310

    CAS  PubMed  PubMed Central  Google Scholar 

  129. O’Hanley P, Lalonde G, Ji G (1991) Alpha-hemolysin contributes to the pathogenicity of piliated digalactoside-binding Escherichia coli in the kidney: efficacy of an α-hemolysin vaccine in preventing renal injury in the BALB/c mouse model of pyelonephritis. Infect Immun 59:1153–1161

    PubMed  PubMed Central  Google Scholar 

  130. Kosikowska P, Berlicki L (2011) Urease inhibitors as potential drugs for gastric and urinary tract infections: a patent review. Expert Opin Ther Pat 21:945–957

    CAS  PubMed  Google Scholar 

  131. Pinkner JS, Remaut H, Buelens F, Miller E, Aberg V, Pemberton N et al (2006) Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria. Proc Natl Acad Sci USA 103:17897–17902

    CAS  PubMed  Google Scholar 

  132. Cusumano CK, Pinkner JS, Han Z, Greene SE, Ford BA, Crowley JR, Henderson JP, Janetka JW, Hultgren SJ (2011) Treatment and prevention of urinary tract infection with orally active FimH inhibitors. Sci Transl Med 3:109–115

    Google Scholar 

  133. Kostakioti M, Hadjifrangiskou M, Hultgren SJ (2013) Bacterial biofilms: development, dispersal, and therapeutic strategies in the dawn of the postantibiotic era. Cold Spring Harb Perspect Med 3:a010306

    PubMed  PubMed Central  Google Scholar 

  134. Koradia P, Kapadia S, Trivedi Y, Chanchu G, Harper A (2019) Probiotic and cranberry supplementation for preventing recurrent uncomplicated urinary tract infections in premenopausal women: a controlled pilot study. Exp Rev Anti-Infect Therapy 17(9):733–740

    CAS  Google Scholar 

  135. Dotis J, Stabouli S, Pavlaki A, Papachristou F, Printza N (2018) Cranberry standardized capsules may prevent recurrences of urinary tract infections in children. Clin Pediatr 1:1007

    Google Scholar 

  136. Das S, Panigrahi S, Panda P (2018a) Antiurobacterial activity of Punica granatum L. seed extract. European J Med Plants 22(2):1–12

    Google Scholar 

  137. Das S, Sahoo KR, Parida B (2018b) Bactericidal activity of Hemidesmus indicus R.Br. root extract against clinically isolated uropathogens. J Med Plant Studies 6(6):180–192

    Google Scholar 

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Acknowledgements

The author expresses sincere gratitude to the Head, Department of Botany, Berhampur University for providing necessary facilities and thanks to Professor B. B. Panda for his consistent guidance and helpful suggestions during the preparation of this manuscript.

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    Sarita Das

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Das, S. Natural therapeutics for urinary tract infections—a review. Futur J Pharm Sci 6, 64 (2020). https://doi.org/10.1186/s43094-020-00086-2

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