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Table 5 Comparison of liposomes and niosomes/proniosomes [42, 46, 47]

From: Recent advances of non-ionic surfactant-based nano-vesicles (niosomes and proniosomes): a brief review of these in enhancing transdermal delivery of drug

Liposomes

Niosomes/ proniosomes

Reference

1. More expensive

1. Less expensive

[123]

2. Require special methods of storage and handling purpose

2. Does not require any special conditions

[123]

3. Phospholipids may be neutral or charged, makes the preparation unstable

3. Non-ionic surfactants are uncharged, makes the preparation more stable

[107]

4. Less shelf-life

4. Long shelf-life

[107]

5. Physical and chemical instability

5. Highly stable

[107]