A review on association and correlation of genetic variants with eating disorders and obesity

Ahamed, Sayed Koushik; Barek, Md Abdul; Roy, Uthpall Kumar; Kouser, Md; Reza, Md Sharif; Mannan, Afifa Binthe; Alam, Md Ashraful; Uddin, S. M. Naim

doi:10.1186/s43094-021-00250-2

Future Journal of Pharmaceutical Sciences

Table 3 Common gene variants are associated with obesity phenotypes

From: A review on association and correlation of genetic variants with eating disorders and obesity

Gene	Description	rs Number	References
FTO	Alpha-ketoglutarate-dependent dioxygenase	rs9939609 rs9930506 rs1121980 rs1421085 rs8050136 rs1558902 rs17817449 rs12149832 rs9940128 rs62033400 rs9941349 rs3751812	[90, 91]
MC4R	Melanocortin 4 receptor	rs17782313 rs571312 rs12970134 rs2331841 rs6567160 rs8089364 rs7234864 rs723486 rs7227255 rs2229616 rs17782313 rs17700144 rs663129 rs571312 rs476828	[92, 93]
PCSK1	Proprotein onvertase subtilisin/kexin type 1	rs6232 rs6234	[94]
CTNNBL1	Catenin beta like 1	rs6013029	[95]
TMEM18	Transmembrane protein 18	rs6548238 rs2867125 rs4854344 rs7561317 rs11127485	[91, 96]
GNPDA2	Glucosamine-6-phosphate deaminase 2	rs10938397 rs13130484 rs348495	[97, 98]
SH2B1	Src homology 2B adapter protein 1	rs7498665	[97]
KCTD15	Potassium channel tetramerization domain containing 15	rs11084753 rs29941	[91, 97]
MTCH2	Mitochondrial carrier homolog 2	rs10838738 rs3817334	[97, 98]
NEGR1	Neuronal growth regulator 1	rs2815752 rs3101336 rs2568958	[91, 97]
NPC1	Niemann-pick disease, type C1	rs1805081	[99]
MAF	MAF BZIP transcription factor	rs1424233	[99]
PTER	Phosphotriesterase related gene	rs10598503	[99]
PRL	Prolactin gene	rs4712652	[99]
SEC16B	Endoplasmic reticulum export factor	rs10913469	[91]
ETV5	ETS variant 5	rs7647305 rs9816226	[91]
AIF1	Allograft inflammatory factor 1	rs2844479	[91]
BDNF	Brain-derived neurotrophic factor	rs6265 rs4923461 rs10767664 rs2030323 rs988712 rs925946	[91]
FAIM2	Fas apoptotic inhibitory molecule 2	rs7138803 rs7132908	[91]
SDCCAG8	Serologically defined colon cancer antigen 8	rs12145833	[96]
TNKS	Tankyrase	rs17150703	[96]
TFAP2B	Transcription factor AP-2 beta	rs987237 rs987237 rs734597 rs2272903	[98]
MSRA	Methionine sulfoxide reductase A	rs7826222	[100]
LYPLAL1	Lysophospholipase-like 1	rs4846567	[100]
NRXN3	Neurexin 3	rs10146997 rs10150332	[98, 101]
HECTD4	HECT domain E3 ubiquitin protein ligase 4	rs2074356	[102]
GPRC5BB	G protein-coupled receptor, class C, group 5, member Bb	rs12444979	[103]
POMC	Pro-opiomelanocortin	rs713586 rs6545814 rs1561288 rs6752378 rs10182181	[98, 103]
MAP2K5	Mitogen-activated protein kinase 5	rs2241423 rs2241423 rs4776970 rs997295	[98, 103]
GIPR	Gastric inhibitory polypeptide receptor	rs2287019 s11671664	[103]
FANCL	Fanconi anemia complementation group L	rs887912 rs12617233	[103]
TNNI3K	TNNI3 interacting kinase	rs1514175 rs12142020 rs1040070 rs1514174	[98, 103]
TMEM160	Transmembrane protein 160	rs3810291	[103]
CADM2	Cell adhesion molecule 2	rs13078807	[103]
LRP1B	Low-density lipoprotein receptor	rs2890652	[103]
PRKD1	Protein kinase D1	rs11847697 rs12885454	[103]
MTIF3	Mitochondrial translational initiation factor 3	rs4771122	[103]
ZNF608	Zinc finger protein 608	rs48361333	[103]
PTBP2	Polypyrimidine tract binding protein 2	rs1555543	[103]
TUB	Tubby protein homolog	rs4929949	[103]
HMGA1	High mobility group AT-hook 1	rs206936	[103]
MC4R	Melanocortin 4 receptor	rs7227255	[103]
RSPO3	R-spondin 3	rs9491696	[104]
VEGFA	Vascular endothelial growth factor A	rs6905288	[104]
TBX15	T-box transcription factor 15	rs984222	[104]
NFE2L3	Nuclear factor erythroid 2-like factor 3	rs1055144	[104]
GRB14	Growth factor receptor bound protein 14	rs10195252	[104]
DNM3	Dynamin-3	rs1011731	[104]
ITPR2/SSPN	Inositol 1,4,5-trisphosphate receptor type 2	rs718314	[104]
LY86	Lymphocyte antigen 86	rs1294421	[104]
HOXC13	Homeobox protein hox-C13	rs1443512	[104]
ADAMTS9	A disintegrin and metalloproteinase with thrombospondin motifs 9	rs6795735	[104]
ZNRF3	Zinc and ring finger 3	rs4823006	[104]
NISCH	Nischarin gene	rs6784615	[104]
CPEB4	Cytoplasmic polyadenylation element binding protein 4	rs6861681	[104]
RASAL2	RAS protein activator like 2	rs10913469 rs543874 rs574367 rs516636 rs591120	[91, 103]
LYPLAL1	Lysophospholipase-like protein 1	rs2605100	[104]
SLC39A8	Solute carrier family 39 member 8	rs13107325	[103]
NCR3	Natural cytotoxicity triggering receptor 3	rs2844479 rs2260000 rs1077393	[31]
NUDT3	Nudix hydrolase 3	rs206936	[103]
RSPOS	roof plate-specific spondin	rs9491696	[104]
RPL27A	Ribosomal protein L27a	rs4929949	[103]
ITPR2	Nositol 1,4,5-trisphosphate receptor, type 2	rs718314	[104]
FAIM2	Fas apoptotic inhibitory molecule 2	rs7138803	[91]
MTIF3	Mitochondrial translational initiation factor 3	rs4771122	[103]
NRXN3	Neurexin 3	rs10146997	[101]
SH2B1	SH2B adaptor protein 1	rs7498665 rs8049439 rs4788102	[91]
MC4R	Melanocortin 4 receptor	rs17782313 rs12970134 rs17700144	[91, 103]
GIPR	Gastric inhibitory polypeptide receptor	rs2287019	[103]
TMEM18	Transmembrane Protein 18	rs2867125 rs6548238 rs7561317 rs12463617 rs4854344	[91, 103]
QPCTL	Glutaminyl-peptide cyclotransferase like	rs2287019	[91, 103]
ADCY9	Adenylate cyclase 9	rs2531995	[98]
AGBL4	ATP/GTP binding protein like 4	rs657452	[105]
ASB4	Ankyrin repeat and SOCS box containing 4	rs6465468	[105]
CCDC171	Coiled-coil domain containing 171	rs4740619	[105]
CADM1	Cell adhesion molecule 1	rs12286929	[105]
CADM2	Cell adhesion molecule 2	rs13078807	[103]
CALCR	Calcitonin receptor	rs9641123	[105]
CBLN1	Cerebellin 1 precursor	rs2080454	[105]
CDKAL1	CDK5 regulatory subunit associated protein 1 like 1	rs2206734, rs9356744	[106]
CLIP1	CAP-Gly domain containing linker protein 1	rs11057405	[105]
CREB1	CAMP responsive element binding protein 1	rs17203016	[105]
EHBP1	EH domain binding protein 1	rs11688816	[105]
ELAVL4	ELAV like RNA binding protein 4	rs11583200	[105]
EPB41L4B	Erythrocyte membrane protein band 4.1 like 4B	rs6477694	[105]
ERBB4	Erb-B2 receptor tyrosine kinase 4	rs7599312	[105]
ETS2	ETS proto-oncogene 2	rs2836754	[105]
FIGN	Fidgetin, microtubule severing factor	rs1460676	[105]
FHIT	Fragile histidine triad protein	rs2365389	[105]
FOXO3	Forkhead box O3	rs9400239	[105]
GBE1	1,4-Alpha-glucan branching enzyme 1	rs3849570	[105]
GDF15	Growth/differentiation factor 15	rs17724992	[105]
GNAT2	G protein subunit alpha transducin 2	rs17024258	[98]
GP2	Glycoprotein 2	rs12597579	[106]
GRID1	Glutamate ionotropic receptor delta type subunit 1	rs7899106	[105]
GRP	Gastrin releasing peptide	rs7243357	[105]
GRP120	G-protein coupled receptor 120	rs116454156	[107]
HHIP	Hedgehog interacting protein	rs11727676	[105]
HIF1AN	Hypoxia inducible factor 1 subunit alpha inhibitor	rs17094222	[105]
HIP1	Huntingtin Interacting Protein 1	rs1167827	[105]
HMGA1	High mobility group AT-hook 1	rs206936	[103]
HNF4G	Hepatocyte nuclear factor 4 Gamma	rs4735692	[98]
HOXB5	Homeobox B5	rs9299	[106]
HS6ST3	Heparan sulfate sulfotransferases	rs7989336	[98]
HSD17B12	Hydroxysteroid 17-beta dehydrogenase 12	rs2176598	[105]
IFNGR1	Interferon gamma receptor 1	rs13201877	[105]
KAT8	Lysine acetyltransferase 8	rs9925964	[105]
KCNK3	Potassium two pore domain channel subfamily K member 3	rs11126666	[105]
KCNMA1	Potassium calcium-activated channel subfamily M alpha 1	rs2116830	[108]
KLF9	Kruppel like factor 9	rs11142387	[109]
LEPR	Leptin receptor	rs11208659	[110]
LMX1B	LIM homeobox transcription factor 1-beta	rs10733682	[105]
BBS4	Bardet-biedl syndrome 4	rs7164727	[105]
RIT2	GTP-binding protein Rit2	rs7239883	[105]
MAPK3	Mitogen-activated protein kinase 3	rs4787491	[105]
MIR548A2	MicroRNA 548a-2	rs1441264 rs9540493	[105]
MRPS33P4	mitochondrial ribosomal protein S33 pseudogene 4	rs13041126	[98]
NAV1	Neuron navigator 1	rs2820292	[105]
NLRC3	NOD-like receptor family CARD domain containing 3	rs758747	[105]
NT5C2	5'-Nucleotidase, cytosolic II	rs11191560	[105]
NTRK2	Neurotrophic receptor tyrosine kinase 2	rs1211166	[105]
NUP54	Nucleoporin 54	rs17001654	[105]
OLFM4	Olfactomedin 4	rs9568856 rs9568867	[98]
PACS1	Phosphofurin acidic cluster sorting protein 1	rs564343	[110]
PARK2	parkin RBR E3 ubiquitin protein ligase	rs13191362	[99]
PLCD4	Phospholipase C delta 4	rs492400	[99]
PMS2L11	postmeiotic segregation increased 2-like 11	rs2245368	[99]
PRKCH	Protein kinase C Eta	rs1957894	[110]
RABEP1	Rabaptin, RAB GTPase binding effector protein 1	rs1000940	[105]
RALYL	RALY RNA binding protein like	rs2033732	[105]
RARB	Retinoic acid receptor beta	rs6804842	[105]
RASA2	RAS P21 protein activator 2	rs16851483	[105]
RMST	Rhabdomyosarcoma 2 associated transcript	rs11109072	[110]
RPTOR	Regulatory associated protein Of MTOR complex 1	rs7503807	[98]
SBK1	SH3 domain binding kinase 1	rs2650492	[105]
DMXL2	Dmx-like 2	rs3736485	[105]
SMG6	SMG6 nonsense mediated MRNA decay factor	rs9914578	[105]
STXBP6	Syntaxin-binding protein 6	rs10132280	[105]
TAL1	T-cell acute lymphocytic leukemia protein 1	rs977747	[105]
TCF7L2	Transcription factor 7-like 2	rs7903146	[105]
TDRG1	Testis development related 1	rs2033529	[105]
TLR4	Toll-like receptor 4	rs1928295	[105]
TOMM40	Translocase of outer mitochondrial membrane 40 homolog	rs2075650	[106]
UBE2E3	Ubiquitin conjugating enzyme E2 E3	rs1528435	[105]
ZBTB10	Zinc finger and BTB domain containing 10	rs16907751	[105]
ZZZ3	Zinc finger ZZ-type containing 3	rs17381664	[98]

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