Table 2 Master formulation of triamcinolone acetonide eye drops suspension
Sr. # | Excipient | Qty/ mL | Grade | Role/function |
|---|---|---|---|---|
1 | Triamcinolone acetonide | 2.00 mg | BP/USP | Active ingredient |
2 | Polysorbate (Tween 80) | 30.0 mg | USP/NF | Solvent, antioxidant |
3 | PEG-12 glyceryl dimeristate | 70.0 mg | USP/NF | Solubilizer, emulsifier |
4 | Ethyl alcohol | 10 µL | USP/NF | Solvent, antibacterial |
5 | Citric acid anhydrous | 1.0 mg | USP/NF | Antioxidant, preservative |
6 | Sodium citrate dihydrate | 4.0 mg | USP/NF | Anticoagulant, buffers |
7 | Benzalkonium chloride | 0.15 mg | USP/NF | Preservative, antimicrobial agent & surfactant |
8 | Water for injection (q.s) | 1.0 mL | USP/BP | Solvent |