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Table 6 Results of forced degradation studies

From: Stability-indicating method development and validation for the concurrent determination of darunavir, cobicistat, emtricitabine and tenofovir alafenamide by UPLC in bulk and tablet dosage forms

Condition TAF COBI FTC DRV
% Drug recovered %Degradation % Drug recovered %Degradation % Drug Recovered %Degradation % Drug recovered %Degradation
Acid 90.13 9.87 95.23 4.77 93.58 6.42 94.25 5.75
Base 94.06 5.94 95.18 4.82 95.30 4.70 95.09 4.91
Peroxide 95.99 4.01 95.80 4.20 94.55 5.45 94.72 5.28
Thermal 97.66 2.04 97.68 2.32 96.58 3.42 96.88 3.12
UV 98.56 1.44 98.32 1.68 98.06 1.94 97.83 2.17
Neutral 99.44 0.56 99.20 0.80 99.51 0.49 99.58 0.42
  1. TAF tenofovir alafenamide, COBI cobicistat, FTC emtricitabine, DRV darunavir, % percentage, UV ultraviolet