Future Journal of Pharmaceutical Sciences

Table 6 Results of forced degradation studies

From: Stability-indicating method development and validation for the concurrent determination of darunavir, cobicistat, emtricitabine and tenofovir alafenamide by UPLC in bulk and tablet dosage forms

Condition	TAF		COBI		FTC		DRV
Condition	% Drug recovered	%Degradation	% Drug recovered	%Degradation	% Drug Recovered	%Degradation	% Drug recovered	%Degradation
Acid	90.13	9.87	95.23	4.77	93.58	6.42	94.25	5.75
Base	94.06	5.94	95.18	4.82	95.30	4.70	95.09	4.91
Peroxide	95.99	4.01	95.80	4.20	94.55	5.45	94.72	5.28
Thermal	97.66	2.04	97.68	2.32	96.58	3.42	96.88	3.12
UV	98.56	1.44	98.32	1.68	98.06	1.94	97.83	2.17
Neutral	99.44	0.56	99.20	0.80	99.51	0.49	99.58	0.42

TAF tenofovir alafenamide, COBI cobicistat, FTC emtricitabine, DRV darunavir, % percentage, UV ultraviolet

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