Guo L, Ghassemian M, Komives EA, Russell P (2012) Cadmium-induced proteome remodeling regulated by Spc1/Sty1 and Zip1 in fission yeast. Toxicol Sci Off J Soc Toxicol 129(1):200–212. https://doi.org/10.1093/toxsci/kfs179
Article
CAS
Google Scholar
Patil RH, Naveen Kumar M, Kiran Kumar KM, Nagesh R, Kavya K, Babu RL, Ramesh GT, Chidananda Sharma S (2018) Dexamethasone inhibits inflammatory response via down regulation of AP-1 transcription factor in human lung epithelial cells. Gene 645:85–94. https://doi.org/10.1016/j.gene.2017.12.024
Article
CAS
PubMed
Google Scholar
Acton QA (2013) Autoimmune diseases: new insights for the healthcare professional, 2013th edn. ScholarlyEditions, Atlanta
Google Scholar
Parameswaran S, Balasubramanian S, Babai N, Qiu F, Eudy JD, Thoreson WB, Ahmad I (2010) Induced pluripotent stem cells generate both retinal ganglion cells and photoreceptors: therapeutic implications in degenerative changes in glaucoma and age-related macular degeneration. Stem cells (Dayton, Ohio) 28(4):695–703. https://doi.org/10.1002/stem.320
Article
CAS
Google Scholar
Wang Q, Wang L (2008) New methods enabling efficient incorporation of unnatural amino acids in yeast. J Am Chem Soc 130(19):6066–6067. https://doi.org/10.1021/ja800894n
Article
CAS
PubMed
Google Scholar
Sedger LM, McDermott MF (2014) TNF and TNF-receptors: from mediators of cell death and inflammation to therapeutic giants—past, present and future. Cytokine Growth Factor Rev 25(4):453–472. https://doi.org/10.1016/j.cytogfr.2014.07.016
Article
CAS
PubMed
Google Scholar
Pearson JM, Vedagiri M (1969) Treatment of moderately severe erythema nodosum leprosum with thalidomide: a double-blind controlled trial. Lepr Rev 40(2):111–116. https://doi.org/10.5935/0305-7518.19690022
Article
CAS
PubMed
Google Scholar
Rutgeerts P, Van Assche G, Vermeire S (2004) Optimizing anti-TNF treatment in inflammatory bowel disease. Gastroenterology 126(6):1593–1610. https://doi.org/10.1053/j.gastro.2004.02.070
Article
CAS
PubMed
Google Scholar
Randall T (1990) Thalidomide has 37-year history. JAMA 263(11):1474. https://doi.org/10.1001/jama.1990.03440110028006
Article
PubMed
Google Scholar
Ito T, Ando H, Handa H (2011) Teratogenic effects of thalidomide: molecular mechanisms. Cell Mol Life Sci 68(9):1569–1579. https://doi.org/10.1007/s00018-010-0619-9
Article
CAS
PubMed
Google Scholar
Spilker B, Fitzsimmons S, Horan MJDDR (1999) US drug and biologic approvals in 1998. 48
Tseng S, Pak G, Washenik K, Pomeranz MK, Shupack JL (1996) Rediscovering thalidomide: a review of its mechanism of action, side effects, and potential uses. J Am Acad Dermatol 35(6):969–979. https://doi.org/10.1016/s0190-9622(96)90122-x
Article
CAS
PubMed
Google Scholar
Noman AS, Koide N, Hassan F, IE-Khuda I, Dagvadorj J, Tumurkhuu G, Islam S, Naiki Y, Yoshida T, Yokochi T (2009) Thalidomide inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production via down-regulation of MyD88 expression. Innate Immun 15(1):33–41. https://doi.org/10.1177/1753425908099317
Article
CAS
PubMed
Google Scholar
Yagyu T, Kobayashi H, Matsuzaki H, Wakahara K, Kondo T, Kurita N, Sekino H, Inagaki K, Suzuki M, Kanayama N, Terao T (2005) Thalidomide inhibits tumor necrosis factor-α-induced interleukin-8 expression in endometriotic stromal cells, possibly through suppression of nuclear factor-κB activation. J Clin Endocrinol Metab 90(5):3017–3021. https://doi.org/10.1210/jc.2004-1946%JTheJournalofClinicalEndocrinology&Metabolism
Article
CAS
PubMed
Google Scholar
Majumder S, Sreedhara SR, Banerjee S, Chatterjee S (2012) TNF α signaling beholds thalidomide saga: a review of mechanistic role of TNF-α signaling under thalidomide. Curr Top Med Chem 12(13):1456–1467. https://doi.org/10.2174/156802612801784443
Article
CAS
PubMed
Google Scholar
He MM, Smith AS, Oslob JD, Flanagan WM, Braisted AC, Whitty A, Cancilla MT, Wang J, Lugovskoy AA, Yoburn JC, Fung AD, Farrington G, Eldredge JK, Day ES, Cruz LA, Cachero TG, Miller SK, Friedman JE, Choong IC, Cunningham BC (2005) Small-molecule inhibition of TNF-alpha. Science (New York, NY) 310(5750):1022–1025. https://doi.org/10.1126/science.1116304
Article
CAS
Google Scholar
Laskowski RA, Jabłońska J, Pravda L, Vařeková RS, Thornton JM (2018) PDBsum: structural summaries of PDB entries. Protein Sci Publ Protein Soc 27(1):129–134. https://doi.org/10.1002/pro.3289
Article
CAS
Google Scholar
Moreira AL, Sampaio EP, Zmuidzinas A, Frindt P, Smith KA, Kaplan G (1993) Thalidomide exerts its inhibitory action on tumor necrosis factor alpha by enhancing mRNA degradation. J Exp Med 177(6):1675–1680. https://doi.org/10.1084/jem.177.6.1675
Article
CAS
PubMed
Google Scholar
Sampaio EP, Sarno EN, Galilly R, Cohn ZA, Kaplan G (1991) Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes. J Exp Med 173(3):699–703. https://doi.org/10.1084/jem.173.3.699
Article
CAS
PubMed
Google Scholar
Spessard GO (1998) ACD Labs/LogP dB 3.5 and ChemSketch 3.5. J Chem Inf Comput Sci 38:1250–1253
Article
CAS
Google Scholar
Froimowitz M (1993) HyperChem: a software package for computational chemistry and molecular modeling. Biotechniques 14(6):1010–1013
CAS
PubMed
Google Scholar
Goodsell DS, Olson AJ (1990) Automated docking of substrates to proteins by simulated annealing. Proteins 8(3):195–202. https://doi.org/10.1002/prot.340080302
Article
CAS
PubMed
Google Scholar
Morris GM, Goodsell DS, Halliday RS, Huey R, Hart WE, Belew RK, Olson AJ (1998) Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function. J Comput Chem 19(14):1639–1662
Article
CAS
Google Scholar
Cheng F, Li W, Zhou Y, Shen J, Wu Z, Liu G, Lee PW, Tang Y (2012) admetSAR: a comprehensive source and free tool for assessment of chemical ADMET properties. J Chem Inf Model 52(11):3099–3105. https://doi.org/10.1021/ci300367a
Article
CAS
PubMed
Google Scholar
Lipinski CA, Lombardo F, Dominy BW, Feeney PJ (2001) Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev 46(1–3):3–26. https://doi.org/10.1016/s0169-409x(00)00129-0
Article
CAS
PubMed
Google Scholar
Iman M, Davood A (2014) Homology modeling of lanosterol 14α-demethylase of Candida albicans and insights into azole binding. Med Chem Res 23(6):2890–2899. https://doi.org/10.1007/s00044-013-0769-z
Article
CAS
Google Scholar
Ntie-Kang F, Lifongo LL, Mbah JA, Owono LC, Megnassan E, Mbaze LMA, Judson PN, Sippl W, Efange SMN (2013) In silico drug metabolism and pharmacokinetic profiles of natural products from medicinal plants in the Congo basin. In Silico Pharmacol 1:12–12. https://doi.org/10.1186/2193-9616-1-12
Article
PubMed
PubMed Central
Google Scholar
Lin JH, Yamazaki M (2003) Role of P-glycoprotein in pharmacokinetics: clinical implications. Clin Pharmacokinet 42(1):59–98. https://doi.org/10.2165/00003088-200342010-00003
Article
CAS
PubMed
Google Scholar
Ganeshan M, Polachi N, Nagaraja P, Subramaniyan BJ (2015) Antiproliferative activity of N-butanol floral extract from Butea monosperma against hct 116 colon cancer cells; drug likeness properties and in silico evaluation of their active compounds toward glycogen synthase kinase-3β/axin and β-catenin/T-cell factor-4 protein complex. Asian J Pharm Clin Res. 8:134–141
Google Scholar
Haslett PA, Roche P, Butlin CR, Macdonald M, Shrestha N, Manandhar R, Lemaster J, Hawksworth R, Shah M, Lubinsky AS, Albert M, Worley J, Kaplan G (2005) Effective treatment of erythema nodosum leprosum with thalidomide is associated with immune stimulation. J Infect Dis 192(12):2045–2053. https://doi.org/10.1086/498216
Article
CAS
PubMed
Google Scholar
Sheskin J (1965) Thalidomide in the treatment of lepra reactions. Clin Pharmacol Ther 6:303–306. https://doi.org/10.1002/cpt196563303
Article
CAS
PubMed
Google Scholar
Corral LG, Muller GW, Moreira AL, Chen Y, Wu M, Stirling D, Kaplan G (1996) Selection of novel analogs of thalidomide with enhanced tumor necrosis factor alpha inhibitory activity. Mol Med (Cambridge, Mass) 2(4):506–515
Article
CAS
Google Scholar
Zeldis JB, Knight R, Hussein M, Chopra R, Muller G (2011) A review of the history, properties, and use of the immunomodulatory compound lenalidomide. Ann N Y Acad Sci 1222:76–82. https://doi.org/10.1111/j.1749-6632.2011.05974.x
Article
CAS
PubMed
Google Scholar
Belarbi K, Jopson T, Tweedie D, Arellano C, Luo W, Greig NH, Rosi S (2012) TNF-α protein synthesis inhibitor restores neuronal function and reverses cognitive deficits induced by chronic neuroinflammation. J Neuroinflammation 9(1):23. https://doi.org/10.1186/1742-2094-9-23
Article
CAS
PubMed
PubMed Central
Google Scholar
Fujimoto H, Noguchi T, Kobayashi H, Miyachi H, Hashimoto Y (2006) Effects of immunomodulatory derivatives of thalidomide (IMiDs) and their analogs on cell-differentiation, cyclooxygenase activity and angiogenesis. Chem Pharm Bull 54(6):855–860. https://doi.org/10.1248/cpb.54.855
Article
CAS
Google Scholar
Aragon-Ching JB, Li H, Gardner ER, Figg WD (2007) Thalidomide analogues as anticancer drugs. Recent Pat Anticancer Drug Discov 2(2):167–174. https://doi.org/10.2174/157489207780832478
Article
CAS
PubMed
PubMed Central
Google Scholar
Schey SA, Fields P, Bartlett JB, Clarke IA, Ashan G, Knight RD, Streetly M, Dalgleish AG (2004) Phase I study of an immunomodulatory thalidomide analog, CC-4047, in relapsed or refractory multiple myeloma. J Clin Oncol Off J Am Soc Clin Oncol 22(16):3269–3276. https://doi.org/10.1200/jco.2004.10.052
Article
CAS
Google Scholar
Fala L (2015) Otezla (apremilast), an oral PDE-4 inhibitor, receives FDA approval for the treatment of patients with active psoriatic arthritis and plaque psoriasis. Am Health Drug Benefits 8(Spec Feature):105–110
PubMed
PubMed Central
Google Scholar
Luo W, Tweedie D, Beedie SL, Vargesson N, Figg WD, Greig NH, Scerba MT (2018) Design, synthesis and biological assessment of N-adamantyl, substituted adamantyl and noradamantyl phthalimidines for nitrite, TNF-α and angiogenesis inhibitory activities. Bioorg Med Chem 26(8):1547–1559. https://doi.org/10.1016/j.bmc.2018.01.032
Article
CAS
PubMed
PubMed Central
Google Scholar
Jung YJ, Tweedie D, Scerba MT, Greig NH (2019) Neuroinflammation as a factor of neurodegenerative disease: thalidomide analogs as treatments. Front Cell Dev Biol 7:313. https://doi.org/10.3389/fcell.2019.00313
Article
PubMed
PubMed Central
Google Scholar
Benjamin E, Hijji YM (2017) A novel green synthesis of thalidomide and analogs. J Chem 2017:6436185. https://doi.org/10.1155/2017/6436185
Article
CAS
Google Scholar