Table 2 Approved miRNA-based drugs for miRNA therapeutics
Drug | Clinical trial | miRNA inhibition | Disease | References |
|---|---|---|---|---|
MRX34 | Phase I | ASOs (2-O′ methyl modifier) | P53/wnt pathway | [61] |
Miravirsen (SPC3649) | Phase I and Phase IIa | phosphorothioate linkage, cholesterol-conjugated AMOs | HCV | [62] |
Cobomarsen (MRG-106) | Phase II | LNA based | Various lymphomas | [63] |
Formiversen | Phase III | PNA based | CMV | [220] |
EXONDYS 51TM | Approved drug | PMO based | Duchenne muscular dystrophy (DMD) | [66] |
Geasense | Phase III | PNA based | BCL2 |