Table 2 Physicochemical properties and release kinetics of the vaginal suppositories using the Korsmeyer–Peppas model
Formulation | pH | Weight (g) | Melting point range (°C) | Crushing strength (N) | Disintegration time (min) | t50 (min) | t80 (min) | Korsmeyer–Peppas | |
|---|---|---|---|---|---|---|---|---|---|
r2 | n | ||||||||
CBC 1 | 5.25 | 0.983 ± 0.058 | 49–55 | 0.80 ± 0.00 | 305.0 ± 4.1 | 156.9 | 275.9 | 0.965 | 0.832 |
CBC 2 | 5.21 | 1.000 ± 0.043 | 45–56 | 1.47 ± 0.28 | 312.0 ± 2.4 | 114.3 | 172.3 | 0.992 | 1.144 |
CBC 3 | 4.62 | 0.967 ± 0.065 | 50–55 | 5.53 ± 0.99 | 322.0 ± 6.2 | 204.3 | 336.0 | 0.981 | 0.945 |
CBC 4 | 5.98 | 0.950 ± 0.067 | 50–56 | 8.87 ± 0.28 | 388.0 ± 14.3 | 95.0 | 129.4 | 0.987 | 1.517 |
CCB | 5.33 | 0.983 ± 0.039 | 40–49 | 7.90 ± 0.00 | 326.0 ± 13.1 | 237.3 | 483.2 | 0.983 | 0.661 |
CPEG | 4.08 | 1.175 ± 0.045 | 50–60 | 32.56 ± 5.42 | 35.0 ± 2.9 | 52.5 | 139.7 | 0.887 | 0.480 |
CBT20C | 4.95 | 0.950 ± 0.052 | 49–52 | 0.59 ± 0.05 | 90.0 ± 8.2 | 76.7 | 115.6 | 0.963 | 1.145 |
CBS20C | 5.12 | 0.975 ± 0.045 | 49–55 | 0.53 ± 0.07 | 77.0 ± 1.7 | 115.0 | 156.1 | 0.997 | 1.538 |
CBSC | 4.39 | 0.992 ± 0.051 | 49–52 | 1.24 ± 0.30 | 88.0 ± 15.2 | 475.8 | – | 0.972 | 0.605 |
CBT20S20C | 5.20 | 1.000 ± 0.043 | 46–50 | 1.04 ± 0.05 | 63.0 ± 0.8 | 442.7 | – | 0.980 | 0.558 |