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Assessment of potential drug–drug interaction knowledge, attitude, and practice among Egyptian hospital and community pharmacists: a cross-sectional multicenter study
Future Journal of Pharmaceutical Sciences volume 10, Article number: 9 (2024)
Abstract
Background
Pharmacists have an important role in preventing prescribing errors and providing appropriate information. They can detect potential drug–drug interactions (DDIs), which are associated with a more extended hospital stay and higher medical costs that lead to substantial financial burdens on healthcare systems. This study aimed to evaluate and assess the knowledge of community and hospital pharmacists toward drug–drug interaction and their attitude and motivation to find DDI information, in addition to identifying the pharmacist factors affecting this knowledge. A cross-sectional multicenter study was conducted using a self-administered questionnaire. Nineteen drug pairs, that are common in clinical practice, were evaluated. This study aimed to evaluate and assess the knowledge of community and hospital pharmacists toward drug–drug interaction and their attitude and motivation to find DDI information, in addition to identifying the pharmacist factors affecting this knowledge.
Results
A total of 4363 pharmacists (2260 community pharmacists and 2103 hospital pharmacists) have completed the survey. The participants' knowledge of DDIs was 58.25%, and there was no significant difference in pharmacist knowledge between community and hospital pharmacists (p = 0.834). The highest correct answer was for sildenafil and isosorbide mononitrate pair 78.8%. The most used source of information was the internet or mobile applications, 47.1%. Participants who always considered PDDIs while prescribing detected more drug interactions than those who did not (p = 0.001).
Conclusion
According to the findings of this study, community and hospital pharmacists had comparable knowledge of DDIs. However, before dispensing uncommon prescriptions, they should consult evidence-based drug information resources and DDI software to identify potential drug interactions.
Background
Drug–drug interactions (DDIs) can be defined as a clinical response to drug administration of a combination of two or more drugs that is different from the expected effects of the individual drugs when given alone [1]. DDIs are one of the medication errors that threaten patient safety as a result of pharmacodynamic or pharmacokinetic interaction between the administered drugs, which can lead to failure of treatment strategy or adverse effects or specific toxicity [2, 3]. The consequences of DDIs vary from minor to severe impacts that can be lethal to patients [4, 5]. The recrudescence of DDIs was found to be about 15–45% of hospitalized patients, with many studies linking DDIs with the increase in the length of hospital stay and healthcare costs [6, 7].
Chronic disease prevalence, polypharmacy, elderly, and cancer patients are all associated with an increased incidence of drug interactions [8,9,10,11]. The management of DDIs is a complex process that requires understanding the risk rating of DDIs mechanism, severity, and reliability and includes risk–benefit assessment [12, 13]
Computerized provider order entry (CPOE) combined with clinical decision support systems (CDSS) are being widely implemented to prevent adverse drug events (ADEs). Still, the effectiveness of these systems remains unclear and does not appear to avoid clinical ADEs reliably. In Egypt, most works identifying potential DDI depend on pharmacists' knowledge or the usage of online applications for drug–drug interactions. Methods for decreasing the possibility of drug interactions include the improvement of the knowledge of healthcare providers, developing systems for checking DDIs, and improvement of patient education regarding drug use [14].
Pharmacists play essential roles in preventing prescribing errors, providing appropriate information, and detecting potential DDIs. For example, community pharmacists can detect and prevent DDI in their pharmacies by detecting potential interactions and giving advice to patients [15]; in addition, published studies have reported that the rates of potential DDIs in hospitalized patients vary from 2.2% to 30%, so the high knowledge of DDIs among hospital pharmacists is essential in the reduction of DDIs complications that are associated with longer hospital stay [16]. In addition, exposure to potential DDIs can result in unnecessary healthcare costs; for example, a study revealed that the costs due to preventable ADRs in the USA and European countries range from €2,851 to €9,015 [17], and these medical costs represent a financial burden on healthcare systems [18, 19].
Despite drug information resources and online websites that are used to identify potential DDIs, the occurrence of possible DDIs is still high, which is usually due to different causes such as availability of pharmacist time, trustiness of patient to pharmacist, and cooperation between patient and pharmacist [20]. The studies of DDIs and their consequences in Egyptian community pharmacies [21] and hospitals [22, 23] are limited, and these interactions may be associated with severe adverse events. Pharmacists in community settings or hospitals play essential roles in DDI detection; however, their knowledge and attitude toward drug interactions do not appear to be studied sufficiently [24]. Most published studies evaluated the knowledge among prescribers [25].Our study aimed to evaluate and assess the knowledge of community and hospital pharmacists toward drug–drug interaction and their attitude and motivation to find DDI information, in addition to identifying the pharmacist factors affecting this knowledge.
Methods
Study design
This cross-sectional multicenter study was conducted using a self-administered questionnaire distributed with pharmacy students' aid between February 1, 2021, and June 30, 2021. Pharmacists working in a private or chain community pharmacy and Ministry of Health or university or private hospital pharmacy were included in the study; those in other sectors, such as industry and academia, were excluded.
Survey questionnaire and data collection
The DDI questionnaire was designed and developed from previous studies that assessed the knowledge of healthcare professionals about DDIs [5, 26, 27]. The structured questionnaire consisted of two sections. The first one was demographic data of the participant pharmacists, including pharmacists' educational level, age, gender, setting, and experience years. The second one contains 19 pairs of common drug interactions in clinical practice [24]. Pharmacists' knowledge was assessed as “No interaction, Contraindication, May be used together with monitoring, and Not sure.”
After finishing the questionnaire, participants were supplied with the correct answers to raise their awareness and knowledge about these potential drug–drug interactions. Participants were informed that their responses and the information was kept securely.
Outcome measures
The primary objectives were to assess the knowledge of community and hospital pharmacists toward potential drug–drug interactions (PDDIs) that reflect the quality of health systems in pharmacies, while the secondary outcomes were to determine the predictor factors impacting pharmacist knowledge of drug interactions.
Sample size calculations
According to Egyptian pharmacists' syndicate records, there are approximately 216,072 registered pharmacists in Egypt, with a confidence level of 97% and a margin of error of 5%. If 50% of the pharmacists would have good knowledge, the minimum acceptable sample size is 470 participants.
Statistical analysis
The data were analyzed using SPSS software version 24 for Analysis. For descriptive Analysis, results were presented as frequencies and percentages. Mann–Whitney test was used for independent nonparametric data. A linear regression model was used to determine the potential predictors of (potential drug–drug interactions) PDDIs knowledge, including participant's age, education, settings, years of practice, and attitude toward PDDIs. For all tests, p < 0.05 was considered statistically significant.
Results
Characteristics of the participants
A total of 4363 pharmacists (2260 community pharmacists and 2103 hospital pharmacists) have completed the survey. As shown in Table 1, the majority (58.4%) aged from 20 to 29 years old. Most (61.1%) had bachelor's degrees, and 69.1% of the participants were from urban regions. About 79.6% of the participants had practiced up to 10 years. There is no significant difference in age and years of practice between community and hospital pharmacists as shown in Table 2.
Knowledge of pharmacists of DDIs
The participant’s knowledge of DDIs was 58.25% (average of correct answers about DDIs). Table 3 summarizes participants’ responses to the DDI questions, presenting the frequencies (percentages) of respondent answers for each of the 19 drug pairs. The lowest correct answer was between alprazolam and itraconazole (n = 778, 17.8%). In contrast, most participants answered the remaining 18 drug pairs questions correctly, and the most correct answer was for sildenafil and isosorbide mononitrate pair (n = 3438, 78.8%).
As shown in Table 4, the highest frequency of correct answers among the community pharmacists was 17 questions, and 0.8% of the community pharmacists answered all the questions incorrectly. However, the highest frequency of correct answers among the hospital pharmacists was 13 questions, and 0.9% answered all 19 questions incorrectly. None of the pharmacists knew all the 19 questions correctly in both groups. The mean rank of the sum of correct answers for the community and hospital pharmacists was 2178.14 and 2186.14, respectively, with a p value of 0.834 (the difference in knowledge between community pharmacists and hospital pharmacists was nonsignificant).
Source of potential DDI information
The sources of DDI information are shown in Fig. 1. The internet or mobile applications were the most used source of information (n = 2057, 47.1%). The least commonly used sources were knowledge bases in Arabic and package inserts (2.2% and 1.2%, respectively).
Attitude toward potential DDIs
As shown in Fig. 2, about 86.98% of the participants consider DDIs when prescribing, with 48.38% agreeing with the statements and 38.60% strongly agreeing, respectively, and only about 1.5% do not consider it when prescribing. More than 88% of participants said that DDI information is essential for their practice. In addition, more than 85% always check DDI when unsure about it, and about 80% are willing to learn about it.
Predictors of PDDIs knowledge
As shown in Table 5, the linear regression model indicates that significant predictors of a higher number of recognized drug pairs were age, education, and attitude toward PDDIs. Participants who always considered PDDIs while prescribing detected more drug interactions than those who did not (p = 0.001). In addition, those who did not check PDDIs when not sure about it had lower scores for PDDIs than those who did (p < 0.001).
Discussion
The recognition of interacting drugs is critical for any healthcare providers, including pharmacists, to decrease the DDIs and, consequently, reduce the drug-related morbidity and mortality that may occur as a result of these interactions [5, 28]. Although thousands of articles on drug interactions have been published and numerous computerized screening systems have been developed, patients continue to suffer from adverse drug interactions. It was found that about twenty percent of the adverse drug effects in the developed countries, which are responsible for more than 700,000 deaths, are due to drug–drug interactions [14]. Possible methods for reducing the risk of drug interactions include improving healthcare providers' knowledge, improving computerized screening systems, providing information on patient risk factors, increasing pharmacogenetic information, more attention to drug administration risk factors, and improving patient education on drug interactions.
In this survey, we assessed the ability of pharmacists to recognize clinically significant drug combinations. It was found that among DDI information sources, internet or mobile applications and medical textbooks were the most used sources of information. The majority of the participants (47.1%) tended to receive information regarding DDIs from electronic sources, which is consistent with a previous study conducted in Iran [29]. The possible explanation for this finding may be the high percentages of young participants in the present study, and people in this age group are usually interested in technology and use it in many fields. A small percentage of the participants in our survey (1.2%) reported that they use package inserts, which is a risk factor for incorrect use of drugs [30].
Our study showed no significant differences in the proportion of community pharmacists and hospital pharmacists who correctly answered the same number of questions about DDIs. The level of the participants' knowledge of DDIs was 58.25% (average of correct answers about DDIs), and this finding is comparable to another study (53.3%) [31]. However, our results are not consistent with another study [24] that revealed a level of knowledge among pharmacists of about 37.3%, but the later study included 26 drug pairs; however, our study included 19 pairs, and these differences in drug pairs may be the cause of the differences in the level of the participant's knowledge on DDIs.
Among the drug pairs selected to assess DDIs knowledge, sildenafil, and isosorbide mononitrate were the most highly recognized drug pairs (78.8%), which is consistent with another study [32]. The lowest recognized pairs were alprazolam and itraconazole (17.8%), which are contraindicated with each other. In accordance with another study [5], even if one justified that the drug combinations classified as contraindicated could be used with close monitoring and considered both choices to be correct, up to 65% of the participants remained unsure if there was a potential interaction or not. In our study, we tried to investigate the predictors of DDI knowledge of participants, including age, education, setting, years of practice, and the participants’ attitudes toward DDIs. It was found that a significant correlation exists between participants’ age and their knowledge level in DDIs. The older participants answered more DDI questions than younger ones, which is consistent with another study that used identical drug pairs as our study [33]. Another study, in contrast to ours, found no connection between age and DDI knowledge level [34], but this may be explained as the later study involved participants of relatively the same age.
Another predictor of DDI knowledge is the education level, which was found to have a significant correlation with the level of knowledge of DDIs. Unexpectedly, participants with bachelor’s and postgraduate certificate holders recognized a higher number of interactions than did those with Ph.D. and board-certified pharmacists, and this finding was in accordance with a study carried out in Khartoum state and showed that pharmacists with bachelor's recognized higher number of DDIs than those with master [31]. The results of our study were in contrary to a previous study [33] that reported that participants' education level did not affect the knowledge level of DDIs. These findings could be due to several factors, including the fact that Ph.D. holders are not recent graduates and may not have as good recall of DDIs, as well as the fact that the majority of pharmacists have bachelor's or postgraduate diploma degrees rather than PhDs and board certifications.
Interestingly, the number of years of experience of the participants was not a significant predictor of DDI knowledge level, and this is consistent with other studies that used different drug pairs for DDI knowledge assessment [5, 31].
Regarding attitudes toward DDIs and their relation to the level of DDI knowledge, it was found that participants who always consider DDIs while prescribing and checking about DDIs when not sure about them recognized a more significant number of DDIs than those who did not, and these results are consistent with previous study conducted in China [33]. This indicates the strong association between the participants' tendency to check references and their knowledge of PDDIs, as proved by the correct recognition of the drug pair interactions.
Astonishingly, this study revealed no significant association between setting (whether community or hospital pharmacists) and the level of their knowledge of DDIs.
The findings of the present study have several implications for practice. This article highlights an important issue that requires urgent attention in Egypt which is the improvement of drug–drug interaction knowledge among community and hospital pharmacists. It is crucial for improving patient safety and healthcare outcomes in the country to ensure the rational and optimal use of drugs. By raising awareness of this issue and identifying potential solutions, this study makes an important contribution to the field of healthcare in Egypt and beyond. Our study has identified some recommendations to improve the knowledge and practice of hospital and community pharmacists regarding DDIs. Based on the study’s findings, it is recommended that continuing education and training programs should be developed for hospital and community pharmacists in Egypt to improve their knowledge of DDIs. The Egyptian Ministry of Health should develop guidelines and protocols for the management of DDIs in hospitals and community pharmacies to ensure consistency in practice. Additionally, these pharmacies should have access to electronic databases that provide up-to-date information on DDIs to support their practice. This study highlights the need for ongoing education and training programs, updated guidelines, and increased resources to support pharmacists in their efforts to provide safe and effective care to patients. Finally, future studies should be conducted to assess the impact of education and training programs on hospital and pharmacists’ knowledge and practice regarding DDIs.
The limitation of our study is that the 19-drug pairs might not be adequate to reflect the extent of knowledge applicable to the vast number of PDDIs. In addition, the study’s sample size may limit the generalizability of the findings. The sample size is small or not representative of the entire population of hospital and community pharmacists in Egypt, so, the results may not accurately reflect the overall knowledge level of pharmacists in the country. Additionally, the study’s reliance on self-reported data from pharmacists introduces the possibility of response bias. Participants may overestimate their knowledge to present themselves in a more favorable light or may underreport their knowledge about DDIs due to various reasons, such as social desirability bias. Furthermore, the study focuses solely on assessing the pharmacists’ knowledge without considering other factors that may influence their ability to apply that knowledge in practice, such as time constraints, workload, or access to resources.
In addition, future studies of larger sample sizes of pharmacists and more drug pairs are required to face the challenges and limitations of this study taking into consideration other factors such as time constraints, workload, or access to resources that may affect their ability to apply that knowledge in practice,
Conclusion
According to our study findings, community and hospital pharmacists had comparable knowledge of DDIs. Pharmacists should improve their knowledge of drug–drug interactions (DDIs) to ensure patient safety. Also, they should consult evidence-based drug information resources and DDI software to identify potential drug interactions before dispensing prescriptions. Developing a system for checking DDIs is necessary.
Availability of data and materials
The datasets generated and analyzed during the current study are available from the corresponding author on a reasonable request.
Abbreviations
- PDDIs:
-
Potential drug–drug interactions
- DDIs:
-
Drug–drug interactions
- CPOE:
-
Computerized provider order entry
- CDSS:
-
Clinical decision support systems
- ADEs:
-
Adverse drug events
References
Pirmohamed M et al (2004) Adverse drug reactions as cause of admission to hospital: prospective analysis of 18,820 patients. BMJ 329(7456):15–19
Lenssen R et al (2016) Analysis of drug-related problems in three departments of a German University hospital. Int J Clin Pharm 38:119–126
Sharifi H, Hasanloei MAV, Mahmoudi J (2014) Polypharmacy-induced drug–drug interactions; threats to patient safety. Drug Res 64:633–637
Baxter K, Preston CL (2010) Stockley’s drug interactions, vol 495. Pharmaceutical Press
Ko Y et al (2008) Prescribers’ knowledge of and sources of information for potential drug-drug interactions: a postal survey of US prescribers. Drug Saf 31:525–536
Dechanont S, Maphanta S, Butthum B, Kongkaew C (2014) Hospital admissions/visits associated with drug–drug interactions: a systematic review and meta-analysis. Pharmacoepidemiol Drug Saf 23(5):489–497
Zheng WY, Richardson LC, Li L, Day RO, Westbrook JI, Baysari MT (2018) Drug–drug interactions and their harmful effects in hospitalised patients: a systematic review and meta-analysis. Eur J Clin Pharmacol 74:15–27
Sánchez-Fidalgo S, Guzmán-Ramos MI, Galván-Banqueri M, Bernabeu-Wittel M, Santos-Ramos B (2017) Prevalence of drug interactions in elderly patients with multimorbidity in primary care. Int J Clin Pharm 39:343–353
Becker ML, Visser LE, van Gelder T, Hofman A, Stricker BHC (2008) Increasing exposure to drug-drug interactions between 1992 and 2005 in people aged ≥ 55 years. Drugs Aging 25:145–152
Guthrie B, Makubate B, Hernandez-Santiago V, Dreischulte T (2015) The rising tide of polypharmacy and drug-drug interactions: population database analysis 1995–2010. BMC Med 13(1):1–10
Bellesoeur A et al (2021) Prevalence of drug–drug interactions in sarcoma patients: key role of the pharmacist integration for toxicity risk management. Cancer Chemother Pharmacol 88:741–751
Hines LE, Malone DC, Murphy JE (2012) Recommendations for generating, evaluating, and implementing drug-drug interaction evidence. Pharmacother J Hum Pharmacol Drug Ther 32(4):304–313
Phansalkar S et al (2013) Criteria for assessing high-priority drug-drug interactions for clinical decision support in electronic health records. BMC Med Inform Decis Mak 13:1–11
Hamadouk RM, Albashair ED, Mohammed FM, Yousef BA (2022) The practice of the community pharmacists in managing potential drug–drug interactions: a simulated patient visits. Integr Pharm Res Pract 11:71–84
Alorfi NM, Alqurashi RS, Algarni AS (2023) Assessment of community pharmacists’ knowledge about drug–drug interactions in Jeddah, Saudi Arabia. Front Pharmacol 14:1209318
Dirin MM, Mousavi S, Afshari AR, Tabrizian K, Ashrafi MH (2014) Potential drug-drug interactions in prescriptions dispensed in community and hospital pharmacies in East of Iran. J Res Pharm Pract 3(3):104
Dimitriadis VK, Dimitsaki S, Chytas A, Gavriilidis GI, Kakalou C, Bonotis P, Natsiavas P (2023) An open-source platform integrating emerging data sources to support multi-modal active pharmacovigilance. Front Drug Saf Regul 19(2):1016042
Chatsisvili A et al (2010) Potential drug–drug interactions in prescriptions dispensed in community pharmacies in Greece. Pharm World Sci 32:187–193
Chen Y-F, Neil KE, Avery AJ, Dewey ME, Johnson C (2005) Prescribing errors and other problems reported by community pharmacists. Ther Clin Risk Manag 1(4):333–342
Chou Y-C, Dang VT, Yen H-Y, Lai K-M (2019) Influence of risk of drug–drug interactions and time availability on patient trust, satisfaction, and cooperation with clinical pharmacists. Int J Environ Res Public Health 16(9):1566
Abuelsoud N (2018) Studying the medication prescribing errors in the egyptian community pharmacies. Asian J Pharm (AJP) 12(01):25–30
Obeid DF, Karara AH (2022) Drug utilization and potential drug–drug interactions within an intensive care unit at a university tertiary care hospital in Egypt. Pharmacy 10(4):96
Sobhy K, AbdelMagged O, Abdelaty K, Khalil D, Abdelgaied M (2021) Potential cardiovascular drug interactions in Egypt: incidence, outcomes, mechanism, and management. Kafrelsheikh Vet Med J 19(2):22–27
Alrabiah Z, Alhossan A, Alghadeer SM, Wajid S, Babelghaith SD, Al-Arifi MN (2019) Evaluation of community pharmacists’ knowledge about drug–drug interaction in Central Saudi Arabia. Saudi Pharm J 27(4):463–466
Hincapie AL, Warholak TL, Hines LE, Taylor AM, Malone DC (2012) Impact of a drug-drug interaction intervention on pharmacy and medical students’ knowledge and attitudes: a 1-year follow-up. Res Social Adm Pharm 8(5):472–477
Momo K, Homma M, Kohda Y, Ohkoshi N, Yoshizawa T, Tamaoka A (2006) Drug interaction of tizanidine and ciprofloxacin: case report. Clin Pharmacol Ther 80(6):717–719
Gilligan AM, Warholak TL, Murphy JE, Hines LE, Malone DC (2011) Pharmacy students’ retention of knowledge of drug–drug interactions. Am J Pharm Educ 75(6):110
Bories M, Bouzillé G, Cuggia M, Le Corre P (2021) Drug–drug interactions in elderly patients with potentially inappropriate medications in primary care, nursing home and hospital settings: a systematic review and a preliminary study. Pharmaceutics 13(2):266
Nabovati E, Vakili-Arki H, Taherzadeh Z, Saberi MR, Abu-Hanna A, Eslami S (2017) A survey of attitudes, practices, and knowledge regarding drug–drug interactions among medical residents in Iran. Int J Clin Pharm 39:560–568
Holloway K, van Dijk L (2011) Rational use of medicines
Tokka ASA, Idris KMA (2017) Assessment of the awareness, knowledge, attitude, and practice of sudanese community pharmacists, in Khartoum State, about drug interactions. World J Pharm Res 6(4):409–426
Glassman PA, Simon B, Belperio P, Lanto A (2002) Improving recognition of drug interactions: benefits and barriers to using automated drug alerts. Med Care 40:1161–1171
Yuan J, Shen C, Wang C, Shen G, Han B (2021) Assessment of physician’s knowledge of potential drug-drug interactions: an online survey in China. Front Med (Lausanne) 8:650369
Saverno KR, Malone DC, Kurowsky J (2009) Pharmacy students’ ability to identify potential drug-drug interactions. Am J Pharm Educ 73(2):27
Acknowledgements
With much respect and appreciation, we wish to thank all faculty of pharmacy October 6 University level 4 students for their participation in questionnaire distribution among hospital and community pharmacists.
Funding
This research received no specific Grant from any funding agency in the public, commercial, or not-for-profit sectors.
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Contributions
Study conception and design were done by EAW, MA, and AE. Data analysis and interpretation were performed by AEAW, AE, YSAD, and EMS. EAW, AEAW, MA, AE, and EMS helped in drafting, revision of the paper, and final approval of the published version.
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Ethics approval and consent to participate
All procedures performed in the study involving human participants were in accordance with the ethical standards of Faculty of pharmacy October 6 University ethics committee and with the 1964 Declaration of Helsinki and its later amendments. The study was received approval from the Ethics Committee and institutional review boards of October 6 University (Approval Number: PR-Ph-2112005). Pharmacist’s participation in this survey was voluntary. Informed consent was obtained from all participants. They were asked before questionnaire if they participate in this study, and they able to refuse take part in the research or exit the survey at any time without penalty. Pharmacists were only required to complete the questionnaire once. Participants informed that their personal details were not linked to their responses and the information were kept securely.
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Wahsh, E.A., Warda, A.E.A., Abdallah, M.S. et al. Assessment of potential drug–drug interaction knowledge, attitude, and practice among Egyptian hospital and community pharmacists: a cross-sectional multicenter study. Futur J Pharm Sci 10, 9 (2024). https://doi.org/10.1186/s43094-024-00580-x
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DOI: https://doi.org/10.1186/s43094-024-00580-x